ArticleClinical mass spectrometry (Del Mar, Calif.)2018
Real-time mass spectrometric identification of metabolites characteristic of chronic obstructive pulmonary disease in exhaled breath.
Article in Clinical mass spectrometry (Del Mar, Calif.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Exhaled breath volatile organic compounds (VOCs) detection methods: GC-MS versus eNose in COPD diagnosis-a systematic review and meta-analysis.BMC pulmonary medicine · 2025Pooled it
- Current data processing methods and reporting standards for untargeted analysis of volatile organic compounds using direct mass spectrometry: a systematic review.Metabolomics : Official journal of the Metabolomic Society · 2024Pooled it
- Exhaled volatile organic compounds analysis in clinical pediatrics: a systematic review.Pediatric research · 2021Pooled it
- A Few-Shot SE-Relation Net-Based Electronic Nose for Discriminating COPD.Sensors (Basel, Switzerland) · 2025Article
- Exploring exhaled volatile organic compounds as potential biomarkers in anti-MDA5 antibody-positive interstitial lung disease.Molecular and cellular biochemistry · 2025Article
- Exhaled volatile organic compounds as novel biomarkers for early detection of COPD, asthma, and PRISm: a cross-sectional study.Respiratory research · 2025Article
- Advancements in Breathomics: Special Focus on Electrochemical Sensing and AI for Chronic Disease Diagnosis and Monitoring.ACS omega · 2025Review
- Article
- Internal Standard Addition System for Online Breath Analysis.Analytical chemistry · 2024Article
- The role of volatile organic compounds for assessing characteristics and severity of non-cystic fibrosis bronchiectasis: an observational study.Frontiers in medicine · 2024Article
- A mass spectrometry-based strategy for investigating volatile molecular interactions in microbial consortia: unveiling aFrontiers in microbiology · 2024Article
- Update on metabolomic findings in COPD patients.ERJ open research · 2023Review
- UHPLC-MS/MS-Based Identity Confirmation of Amino Acids Involved in Response to and Side Effects from Antiseizure Medications.Journal of proteome research · 2023Article
- Review
- Mask assistance to colorimetric sniffers for detection of Covid-19 disease using exhaled breath metabolites.Sensors and actuators. B, Chemical · 2022Article
- Metabolome Features of COPD: A Scoping Review.Metabolites · 2022Article
- A systematic review of the diagnostic accuracy of volatile organic compounds in airway diseases and their relation to markers of type-2 inflammation.ERJ open research · 2021Article
- Artificial Breath Classification Using XGBoost Algorithm for Diabetes Detection.Sensors (Basel, Switzerland) · 2021Article
- Breathomics for the clinician: the use of volatile organic compounds in respiratory diseases.Thorax · 2021Review
- A Literature Review and Framework Proposal for Halitosis Assessment in Cigarette Smokers and Alternative Nicotine-Delivery Products Users.Frontiers in oral health · 2021Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: New mass spectrometry (MS) techniques analysing exhaled breath have the potential to better define airway diseases. Here, we present our work to profile the volatile organic compounds (VOCs) in exhaled breath from patients with chronic obstructive pulmonary disease (COPD), using real-time MS, and relate this disease-specific breath profile to functional disease markers. Methods: In a matched cohort study, patients with COPD, according to GOLD criteria, were recruited. Exhaled breath analysis by untargeted MS was performed using secondary electrospray ionization - high-resolution MS (SESI-HRMS). Results: Exhaled breath from 22 patients with COPD (mean age 58.6 ± 6.9 years, FEV Conclusion: Real-time breath analysis by SESI-MS allows molecular profiling of exhaled breath, can distinguish patients with COPD from matched healthy controls and provides insights into the disease pathogenesis.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.