ArticleComputing in cardiology2023
Uncertainty Quantification of the Effect of Variable Conductivity in Ventricular Fibrotic Regions on Ventricular Tachycardia.
Article in Computing in cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- A computational study on the influence of antegrade accessory pathway location on the 12-lead electrocardiogram in Wolff-Parkinson-White syndrome.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025Article
- Uncertainty Quantification of Fibrotic Conductivity Effects on Computational Model-Derived Ablation of Atypical Left Atrial Flutter.Computing in cardiology · 2024Article
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Authors and funding
11 authors.
Funding
Abstract
Ventricular tachycardia (VT) is a life-threatening cardiac arrhythmia for which a common treatment pathway is electroanatomical mapping and ablation. Recent advances in both noninvasive ablation techniques and computational modeling have motivated the development of patient-specific computational models of VT. Such models are parameterized by a wide range of inputs, each of which is associated with an often unknown amount of error and uncertainty. Uncertainty quantification (UQ) is a technique to assess how variability in the inputs to a model affects its outputs. UQ has seen increased attention in computational cardiology as an avenue to further improve, understand, and develop patient-specific models. In this study we applied polynomial chaos-based UQ to explore the effect of varying the tissue conductivity of fibrotic border zones in a patient-specific model on the resulting VT simulation. We found that over a range of inputs, the model was most sensitive to fibrotic sheet direction, and uncertainty in fibrotic conductivity resulted in substantial variability in the VT reentry duration and cycle length. Overall, this study paves the way for future UQ applications to improve and understand VT models.
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Registered trials
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