ArticleFrontiers in physiology2024
Non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and hypertension in American adults: a NHANES cross-sectional study.
Article in Frontiers in physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34 citing papers in PubMed.
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- Association of the ratio of non-HDL-cholesterol to HDL-cholesterol with clinical and pathological characteristics in diabetic kidney disease.BMC nephrology · 2026Article
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- Association Between NHHR and Future Cardiovascular Disease Among Patients With CKM Stages 0-3: A Nationwide Prospective Cohort Study.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
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- Association of radiation exposure and blood lipid derived indices with hypertension risk in radiation workers.Frontiers in public health · 2026Article
- Association between blood lipid levels, BMI, and hypertension among employees in petrochemical enterprises.Frontiers in cardiovascular medicine · 2026Article
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- Association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and carotid plaque: a retrospective cohort study.Frontiers in nutrition · 2026Article
- Non-HDL-to-HDL cholesterol ratio predicts incident T2DM and CHD in non-alcoholic fatty liver disease: evidence from a large clinical cohort and NHANES.Frontiers in nutrition · 2026Article
- Association between non-HDL-C/HDL-C ratio and sarcopenia in US adults: a population-based study.Journal of health, population, and nutrition · 2025Article
- Relation of the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio to residual risk in anticoagulated patients with atrial fibrillation: a report from the prospective Murcia AF Project III cohort.Cardiovascular diabetology · 2025Observational
- Association of remnant cholesterol with new-onset hypertension among middle-aged and older adults in China.Scientific reports · 2025Article
- The quality and reliability of short videos about hypertension on TikTok: a cross-sectional study.Scientific reports · 2025Article
- The association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and the risk of insulin resistance: results from the NHANES 2003-2016.BMC endocrine disorders · 2025Article
- Crosstalk Between Metabolic Biomarkers and Pulse Wave Analysis in Hypertensive Patients.Biomedicines · 2025Article
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2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Objectives: The relationship between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and hypertension remains uncertain, warranting further investigation. This study aims to elucidate the association between NHHR and hypertension. Methods: A comprehensive cross-sectional stratified survey involving 30,602 participants aged 20 years and older was conducted using the National Health and Nutrition Examination Survey (NHANES) dataset from 2001 to 2018. NHHR was calculated as [total cholesterol (TC) - high-density lipoprotein cholesterol (HDL-C)]/HDL-C. The relationship between NHHR and hypertension was examined using weighted multiple linear regression, smooth curve fitting, hierarchical analysis, and interaction testing. Results: The mean age of participants was 49.82 ± 17.64 years, with 15,266 women included. The average NHHR was 2.94 ± 0.56. A positive correlation between NHHR and hypertension was observed. Stratification of NHHR into quartiles, in the fully adjusted Model 3, revealed that individuals in the highest NHHR quartile had a 60% increased risk of hypertension for each unit increase in NHHR compared to those in the lowest quartile. Interaction tests indicated that the relationship between NHHR and hypertension remained consistent across subgroups, except for gender, age, education, and smoking status, which influenced this association. Conclusion: Analysis of NHANES data from 2001 to 2018 demonstrated a consistent positive association between NHHR and hypertension. NHHR may provide potential assistance in hypertension prevention and diagnosis.
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