ArticleMetabolism and target organ damage2023
Fructose as a novel nutraceutical for acetaminophen (APAP)-induced hepatotoxicity.
Article in Metabolism and target organ damage, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- The gut-liver axis in drug-induced liver injury (DILI): Interplay between gut microbiota, intestinal barrier, and immune system.Acta pharmaceutica Sinica. B · 2026Review
- Nutraceutical Potential and Food Safety of Fructose in Soda and Diet Beverages.Foods (Basel, Switzerland) · 2025Article
- Association of glycemic control with Long COVID in patients with type 2 diabetes: findings from the National COVID Cohort Collaborative (N3C).BMJ open diabetes research & care · 2025Article
- Unveiling risk factors for post-COVID-19 syndrome development in people with type 2 diabetes.Frontiers in endocrinology · 2024Article
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Authors and funding
7 authors.
Funding
Abstract
Acetaminophen (APAP) is the most widely used analgesic in the world. APAP overdose can cause severe hepatotoxicity and therefore is the most common cause of drug-induced liver injury. The only approved treatment for APAP overdose is N-acetyl-cysteine (NAC) supplementation. However, the narrow efficacy window of the drug severely limits its clinical use, prompting the search for other therapeutic options to counteract APAP toxicity. Recent research has pointed to fructose as a novel nutraceutical for APAP-induced liver injury. This review summarizes the current understanding of the molecular mechanisms underlying APAP-induced liver injury, introduces how fructose supplementation could prevent and treat APAP liver toxicity with a focus on the ChREBPα-FGF21 pathway, and proposes possible future directions of study.
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