Evidence map›Paper›PMID 39193113›Full record

ArticleJBMR plus2024

Idiopathic juvenile osteoporosis-a polygenic disorder?

Emma Wade, Katie Mulholland, Ian Shaw, Tim Cundy, Stephen Robertson

Abstract read
In one paragraph

Article in JBMR plus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Bone Material Properties in Male Idiopathic Osteoporosis.Calcified tissue international · 2025
    Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Emma WadeDepartment of Women's & Children's Health, Dunedin School of Medicine, University of Otago, Dunedin, 9016, New Zealand.
Katie MulhollandDepartment of Women's & Children's Health, Dunedin School of Medicine, University of Otago, Dunedin, 9016, New Zealand.
Ian ShawDepartment of Pediatrics, Southland Hospital, Invercargill, 9812, New Zealand.
Tim CundyDepartment of Medicine, Faculty of Medical & Health Sciences, University of Auckland, Auckland, 1023, New Zealand.ORCID https://orcid.org/0000-0003-4890-9400
Stephen RobertsonDepartment of Women's & Children's Health, Dunedin School of Medicine, University of Otago, Dunedin, 9016, New Zealand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Idiopathic juvenile osteoporosis (IJO) is a rare condition presenting with vertebral and metaphyseal fractures that affects otherwise healthy prepubertal children. Bone mineral density (BMD) measurements are very low. The primary problem appears to be deficient bone formation, with a failure to accrue bone normally during growth. The onset in childhood suggests IJO is a genetic disorder, and a number of reports indicate that some children carry heterozygous pathogenic variants in genes known to be associated with defective osteoblast function and low bone mass, most commonly

Indexed as

bone densityhypophosphatasiaidiopathic juvenile osteoporosispolygenic inheritancequantitative histomorphometrywhole genome sequencing

Identifiers

PMID39193113
PMCPMC11347881

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.