Evidence map›Paper›PMID 39193001›Full record

Observational studyWorld journal of gastroenterology2024

Alterations in the gut microbiome after transjugular intrahepatic portosystemic shunt in patients with hepatitis B virus-related portal hypertension.

Hong-Wei Zhao, Jin-Long Zhang, Fu-Quan Liu, Zhen-Dong Yue, Lei Wang, Yu Zhang, Cheng-Bin Dong, Zhen-Chang Wang

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in World journal of gastroenterology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hong-Wei ZhaoDepartment of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
Jin-Long ZhangDepartment of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
Fu-Quan LiuDepartment of Interventional Radiology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.
Zhen-Dong YueDepartment of Interventional Radiology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.
Lei WangDepartment of Interventional Radiology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.
Yu ZhangDepartment of Interventional Radiology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.
Cheng-Bin DongDepartment of Interventional Radiology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.
Zhen-Chang WangDepartment of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China. cjr.wzhch@vip.163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGut microbiota (GM) affects the progression and response to treatment in liver diseases. The GM composition is diverse and associated with different etiologies of liver diseases. Notably, alterations in GM alterations are observed in patients with portal hypertension (PH) secondary to cirrhosis, with hepatitis B virus (HBV) infection being a major cause of cirrhosis in China. Thus, understanding the role of GM alterations in patients with HBV infection-related PH is essential.

aimTo evaluate GM alterations in patients with HBV-related PH after transjugular intrahepatic portosystemic shunt (TIPS) placement.

methodsThis was a prospective, observational clinical study. There were 30 patients (with a 100% technical success rate) recruited in the present study. Patients with esophagogastric variceal bleeding due to HBV infection-associated PH who underwent TIPS were enrolled. Stool samples were obtained before and one month after TIPS treatment, and GM was analyzed using 16S ribosomal RNA amplicon sequencing.

resultsOne month after TIPS placement, 8 patients developed hepatic encephalopathy (HE) and were assigned to the HE group; the other 22 patients were assigned to the non-HE group. There was no substantial disparity in the abundance of GM at the phylum level between the two groups, regardless of TIPS treatment (all,

conclusionIntestinal microbiota-related synergism may predict the risk of HE following TIPS placement in patients with HBV-related PH. Prophylactic microbiome therapies may be useful for preventing and treating HE after TIPS placement.

Indexed as

Gastrointestinal MicrobiomeHepatic EncephalopathyHepatitis B virusHypertension, PortalPortasystemic Shunt, Transjugular IntrahepaticAdultAgedBacteriaChinaDysbiosisEsophageal and Gastric VaricesFecesFemaleGastrointestinal HemorrhageHepatitis BHumansRNA, Ribosomal, 16SGut microbiotaHepatic encephalopathyHepatitis B virusPortal hypertensionTransjugular intrahepatic portosystemic shunt

Identifiers

PMID39193001
PMCPMC11346157

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.