Evidence map›Paper›PMID 39192922›Full record

ReviewCureus2024

Exploring Erenumab's Efficacy and Safety for Migraine Prevention in Real-World Settings: A Systematic Review.

Mah Rukh Nisar, Rudrani Kotha, Sabaa I Saad-Omer, Shivani Singh, Oluwatoba T Olayinka, Jaslin Orelus, Ann Kashmer Yu

Abstract readReview
In one paragraph

Review in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mah Rukh NisarNeurology, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA.
Rudrani KothaInternal Medicine, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA.
Sabaa I Saad-OmerInternal Medicine, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA.
Shivani SinghInternal Medicine, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA.
Oluwatoba T OlayinkaClinical Sciences, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA.
Jaslin OrelusEmergency Medicine, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA.
Ann Kashmer YuInternal Medicine, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Migraine causes debilitating headaches and significantly impacts quality of life. Effective migraine-specific treatments have been lacking until the advent of monoclonal antibodies (mAbs) targeting calcitonin gene-related peptide (CGRP) receptors, which have expanded therapy options for migraine treatment. This study explores the short- and long-term efficacy and safety of erenumab in migraine treatment. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 criteria guided this systematic review. Five databases - PubMed, PubMed Central, Google Scholar, ScienceDirect, and Sage Journal - were searched for published, freely accessible, full-text articles in English from the past five years. Eligible patients included those with episodic or chronic migraines who received erenumab intervention. From an initial search yielding 680 relevant studies, 12 prospective observational cohort studies were selected after assessing the risk of bias through the Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies. All included studies demonstrated a significant reduction in monthly migraine days (MMDs) by the end of the treatment period, with mild adverse effects observed. No significant short-term or long-term safety concerns were identified.

Indexed as

anti-cgrp mabchronic migraineepisodic migraineerenumabmigrainetreatment resistant migraine

Identifiers

PMID39192922
PMCPMC11349244

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.