Evidence map›Paper›PMID 39192882›Full record

ArticleFrontiers in human neuroscience2024

Neurologic manifestations of Long COVID in Colombia: a comparative analysis of post-hospitalization vs. non-hospitalized patients.

Carolina Hurtado, Diego Fernando Rojas-Gualdrón, Gina S Pérez Giraldo, Esteban Villegas Arbelaez, Salvador Ernesto Medina Mantilla, Mariana Campuzano-Sierra, Santiago Ospina-Patino, Mariana Arroyave-Bustamante, Valeria Uribe-Vizcarra, Daniel Restrepo-Arbelaez and 10 more

Abstract read
In one paragraph

Article in Frontiers in human neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Carolina HurtadoSchool of Medicine, CES University, Medellín, Colombia.
Diego Fernando Rojas-GualdrónSchool of Medicine, CES University, Medellín, Colombia.
Gina S Pérez GiraldoNeurology Department, Medical University of South Carolina, Charleston, SC, United States.
Esteban Villegas ArbelaezClínica CES, Medellín, Colombia.
Salvador Ernesto Medina MantillaClínica CES, Medellín, Colombia.
Mariana Campuzano-SierraSchool of Medicine, CES University, Medellín, Colombia.
Santiago Ospina-PatinoSchool of Medicine, CES University, Medellín, Colombia.
Mariana Arroyave-BustamanteSchool of Medicine, CES University, Medellín, Colombia.
Valeria Uribe-VizcarraSchool of Medicine, CES University, Medellín, Colombia.
Daniel Restrepo-ArbelaezSchool of Medicine, CES University, Medellín, Colombia.
Paul CardonaSchool of Medicine, CES University, Medellín, Colombia.
Julián Llano-PiedrahitaSchool of Medicine, CES University, Medellín, Colombia.
Santiago Vásquez-BuilesSchool of Medicine, CES University, Medellín, Colombia.
Esteban Agudelo-QuinteroSchool of Medicine, CES University, Medellín, Colombia.
Juliana Vélez-ArroyaveSchool of Medicine, CES University, Medellín, Colombia.
Sebastián MengesSchool of Medicine, CES University, Medellín, Colombia.
Millenia JimenezThe Ken & Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.
Janet MillerThe Ken & Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.
Yina M QuiqueShirley Ryan AbilityLab, Chicago, IL, United States.
Igor J KoralnikThe Ken & Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To analyze patient-reported outcomes, cognitive function, and persistent symptoms in patients with neurologic post-acute sequelae of SARS-CoV-2 infection (Neuro-PASC) in Colombia. Methods: We recruited patients with laboratory-confirmed COVID-19 and PASC symptoms lasting more than 6 weeks at the CES University and CES Clinic (Medellín, Colombia). We included 50 post-hospitalization Neuro-PASC (PNP) and 50 non-hospitalized Neuro-PASC (NNP) patients. Long-COVID symptoms, cognitive (NIH Toolbox v2.1-Spanish for 18+), patient-reported (PROMIS) outcomes, and relevant medical history were evaluated. Statistical analyses were performed via generalized linear models. Results: Overall, brain fog (60%), myalgia (42%), and numbness or tingling (41%) were the most common neurological symptoms, while fatigue (74%), sleep problems (46%), and anxiety (44%) were the most common non-neurological symptoms. Compared to NNP, PNP patients showed a higher frequency of abnormal neurological exam findings (64% vs. 42%, Conclusion: Our findings highlight the high incidence and heterogeneity of the neurologic symptoms and impacts of Long COVID even more than 2 years from disease onset. Early detection, emotional support and targeted management of Neuro-PASC patients are warranted.

Indexed as

cognitive dysfunctionCOVID-19neurologic manifestationspatient reported outcome measurespost-acute COVID-19 syndrome

Identifiers

PMID39192882
PMCPMC11347330

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.