ArticleWorld journal of diabetes2024
Association between composite dietary antioxidant index and stroke among individuals with diabetes.
Article in World journal of diabetes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Machine learning and SHAP interpretation for predicting coronary heart disease-diabetes comorbidity with dietary antioxidants.Scientific reports · 2026Article
- Mutual Impact of Dietary Antioxidants andNutrients · 2025Article
- Association of antioxidant markers (SOD, GSH, NO, Catalase) with ischemic stroke severity and recovery outcomes.Journal of medical biochemistry · 2025Article
- Association between composite dietary antioxidant index and rheumatoid arthritis: results from NHANES 2003-2018.International journal of medical sciences · 2025Article
- Association between serum A/G ratio and stroke: data from NHANES 2009-2020.Frontiers in nutrition · 2025Article
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Authors and funding
11 authors.
Funding
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Abstract
backgroundRecent research has underscored the potentially protective role of dietary antioxidants against chronic conditions, such as cardiovascular diseases and stroke. The composite dietary antioxidant index (CDAI), which reflects the overall intake of key dietary antioxidants, has been identified as a crucial metric for exploring this relationship. Although previous research has shown a negative correlation between CDAI levels and stroke risk in prediabetic individuals, there remains a substantial gap in understanding this association among individuals with dia-betes, who are at an inherently greater risk for cerebrovascular events.
aimTo investigate the association between CDAI and stroke risk in individuals with diabetes.
methodsUsing a cross-sectional study design, this investigation analyzed data from the National Health and Nutrition Examination Survey spanning from 2003 to 2018 that included 6735 participants aged over 20 years with diabetes. The CDAI was calculated from 24-h dietary recalls to assess intake of key antioxidants: Vitamins A, C, and E; carotenoids; selenium; and zinc. Multivariate logistic regression and restricted cubic spline analysis were used to rigorously examine the relationship between CDAI and stroke risk.
resultsThe participant cohort, with an average age of 59.5 years and a slight male majority, reflected the broader demographic characteristics of individuals with diabetes. The analysis revealed a strong inverse relationship between CDAI levels and stroke risk. Remarkably, those in the highest quintile of CDAI demonstrated a 43% lower prevalence of stroke compared to those in the lowest quintile, even after adjustments for various confounders. This finding not only highlights the negative association between CDAI and stroke risk but also underscores the significant potential of antioxidant-rich diets in reducing stroke prevalence among patients with diabetes.
conclusionOur findings suggested that CDAI was inversely associated with stroke prevalence among patients with diabetes. These results suggest incorporating antioxidant-rich foods into dietary regimens as a potential strategy for stroke prevention.
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