Evidence map›Paper›PMID 39192734›Full record

ArticleACS chemical biology2024

Disulfide Tethering to Map Small Molecule Binding Sites Transcriptome-wide.

Michelle H Moon, Isaac W Vock, Andrew D Streit, Leah J Connor, Julia Senkina, Jonathan A Ellman, Matthew D Simon

Abstract read
In one paragraph

Article in ACS chemical biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Michelle H MoonDepartment of Molecular Biophysics & Biochemistry, Yale University, New Haven, Connecticut 06511, United States.
Isaac W VockDepartment of Molecular Biophysics & Biochemistry, Yale University, New Haven, Connecticut 06511, United States.
Andrew D StreitDepartment of Chemistry, Yale University, New Haven, Connecticut 06511, United States.
Leah J ConnorDepartment of Molecular Biophysics & Biochemistry, Yale University, New Haven, Connecticut 06511, United States.
Julia SenkinaDepartment of Chemistry, Yale University, New Haven, Connecticut 06511, United States.
Jonathan A EllmanDepartment of Chemistry, Yale University, New Haven, Connecticut 06511, United States.ORCID 0000-0001-9320-5512
Matthew D SimonDepartment of Molecular Biophysics & Biochemistry, Yale University, New Haven, Connecticut 06511, United States.ORCID 0000-0001-7423-5265

Funding

Next-generation C-H functionalization methods for organic synthesis and their applications to biological inquiryR35GM122473 · NIGMS · YALE UNIVERSITY · PI JONATHAN A ELLMAN · 2017 to 2026
$7.6M
Predoc Training at the Interface Chemistry and BiologyT32GM067543 · NIGMS · YALE UNIVERSITY · PI CRAWFORD, JASON MICHAEL · 2003 to 2022
$7.4M
Revealing the dynamics of RNA metabolism with nucleotide recoding chemistryR01GM137117 · NIGMS · YALE UNIVERSITY · PI Matthew David Simon · 2020 to 2026
$2.6M
NIGMS NIH HHS R01 GM137117NIGMS NIH HHS R35 GM122473NIGMS NIH HHS T32 GM067543
6 · The paper itself

Abstract

We report the development of Tether-seq, a transcriptome-wide screen to probe RNA-small molecule interactions using disulfide tethering. This technique uses s

Indexed as

DisulfidesTranscriptomeBinding SitesElectron Transport Complex IVHumansRNASmall Molecule LibrariesDisulfidesElectron Transport Complex IVRNASmall Molecule Libraries

Identifiers

PMID39192734
PMCPMC11683664

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.