Evidence map›Paper›PMID 39192348›Full record

ArticleParasites & vectors2024

First detection of kdr L1014F allele in Anopheles ziemanni and Anopheles pharoensis in Cameroon and distribution of the allele in members of the Anopheles gambiae complex.

Marie Paul Audrey Mayi, Christophe Antonio-Nkondjio, Roland Bamou, Claudia Damiani, Alessia Cappelli, Borel Djiappi-Tchamen, Landre Djamouko-Djonkam, Mahdokht Ilbeigi Khamseh Nejad, Verena Pichler, Irene Ricci and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parasites & vectors, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Complex non-Research square · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Marie Paul Audrey MayiSchool of Biosciences and Veterinary Medicine, University of Camerino, Via Gentile III da Varano, 62032, Camerino, Italy.
Christophe Antonio-NkondjioInstitut de Recherche de Yaoundé (IRY), Organisation de Coordination pour la lutte contre les Endémies en Afrique Centrale (OCEAC), P.O. Box 288, Yaoundé, Cameroon.
Roland BamouInstitut de Recherche de Yaoundé (IRY), Organisation de Coordination pour la lutte contre les Endémies en Afrique Centrale (OCEAC), P.O. Box 288, Yaoundé, Cameroon.
Claudia DamianiSchool of Biosciences and Veterinary Medicine, University of Camerino, CIRM Italian Malaria Network, Via Gentile III da Varano, 62032, Camerino, Italy.
Alessia CappelliSchool of Biosciences and Veterinary Medicine, University of Camerino, CIRM Italian Malaria Network, Via Gentile III da Varano, 62032, Camerino, Italy.
Borel Djiappi-TchamenInstitut de Recherche de Yaoundé (IRY), Organisation de Coordination pour la lutte contre les Endémies en Afrique Centrale (OCEAC), P.O. Box 288, Yaoundé, Cameroon.
Landre Djamouko-DjonkamInstitut de Recherche de Yaoundé (IRY), Organisation de Coordination pour la lutte contre les Endémies en Afrique Centrale (OCEAC), P.O. Box 288, Yaoundé, Cameroon.
Mahdokht Ilbeigi Khamseh NejadSchool of Biosciences and Veterinary Medicine, University of Camerino, Via Gentile III da Varano, 62032, Camerino, Italy.
Verena PichlerDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Irene RicciSchool of Biosciences and Veterinary Medicine, University of Camerino, CIRM Italian Malaria Network, Via Gentile III da Varano, 62032, Camerino, Italy.
Guido FaviaSchool of Biosciences and Veterinary Medicine, University of Camerino, CIRM Italian Malaria Network, Via Gentile III da Varano, 62032, Camerino, Italy. guido.favia@unicam.it.

Funding

European Union-NextGenerationEU PRIN 2022 PNRR MUR P20225TJWB
6 · The paper itself

Abstract

backgroundKnockdown resistance (kdr) is one of the primary resistance mechanisms present in anopheline species. Although this mutation is largely spread across the Anopheles gambiae s.l. members, its prevalence in other species is still not well documented.

methodsThe present study investigated the distribution and allelic frequencies of kdr in An. gambiae s.l., An. pharoensis, and An. ziemanni samples collected in 2022 and 2023 in nine sites spread across five ecogeographical settings in Cameroon. Members of the An. gambiae complex were identified molecularly by polymerase chain reaction (PCR). kdr L1014F and L1014S alleles were screened by PCR and confirmed by sequencing.

resultsAn. gambiae (49.9%), An. coluzzii (36.5%), and An. arabiensis (13%) were identified, and the frequency of the kdr L1014F was high in both An. gambiae and An. coluzzii in all sites. The kdr L1014F allele was detected for the first time in 8 out of 14 An. ziemanni samples examined and in 5 out of 22 An. pharoensis samples examined. The kdr L1014S allele was scarce and found only in the heterozygote "RS" state in An. arabiensis and An. gambiae in Yangah and Santchou.

conclusionsThe present study sheds light on the rapid expansion of the kdr L1014F allele in malaria vectors in Cameroon and stresses the need for surveillance activities also targeting secondary malaria vectors to improve the control of malaria transmission.

Indexed as

AllelesAnophelesGene FrequencyInsecticide ResistanceMosquito VectorsAnimalsCameroonInsecticidesInsect ProteinsMutationPolymerase Chain ReactionInsecticidesInsect ProteinsAnopheles arabiensisAnopheles coluzziiAnopheles gambiaeAnopheles pharoensisAnopheles ziemanniCameroonInsecticide resistancekdr mutationMalaria

Identifiers

PMID39192348
PMCPMC11348551

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.