Evidence map›Paper›PMID 39192034›Full record

ReviewThe EMBO journal2024

Reassessing the unifying hypothesis for hypercontractility caused by myosin mutations in hypertrophic cardiomyopathy.

James A Spudich, Neha Nandwani, Julien Robert-Paganin, Anne Houdusse, Kathleen M Ruppel

Abstract readReview
In one paragraph

Review in The EMBO journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Thick filament molecular interfaces play a critical role in the pathogenesis of hypertrophic cardiomyopathy.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Understanding hypertrophic cardiomyopathy and its regulation by myosin drugs.Protein science : a publication of the Protein Society · 2025
    Article
  18. Article
  19. Article
  20. A FRET assay to monitor different structural states of human β-cardiac myosin including the interacting-heads motif.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

James A SpudichDepartment of Biochemistry, Stanford University School of Medicine, Stanford, CA, 94305, USA. jspudich@stanford.edu.ORCID http://orcid.org/0000-0002-4324-4254
Neha NandwaniDepartment of Biochemistry, Stanford University School of Medicine, Stanford, CA, 94305, USA.ORCID http://orcid.org/0000-0002-6958-3756
Julien Robert-PaganinStructural Motility, Institut Curie, Paris Université Sciences et Lettres, Sorbonne Université, CNRS UMR144, F-75005, Paris, France.ORCID http://orcid.org/0000-0001-6102-2025
Anne HoudusseStructural Motility, Institut Curie, Paris Université Sciences et Lettres, Sorbonne Université, CNRS UMR144, F-75005, Paris, France.ORCID http://orcid.org/0000-0002-8566-0336
Kathleen M RuppelDepartment of Biochemistry, Stanford University School of Medicine, Stanford, CA, 94305, USA. kruppel@stanford.edu.ORCID http://orcid.org/0000-0002-0971-5331

Funding

MYOSIN MOVEMENT IN VITRO: MOLECULAR CHARACTERIZATIONR01GM033289 · NIGMS · STANFORD UNIVERSITY · PI SPUDICH, JAMES · 1985 to 2024
$13.6M
From proteins to cells to tissues: A multi-scale assessment of biomechanical regulation by the myosin molecular motorRM1GM131981 · NIGMS · STANFORD UNIVERSITY · PI BERNSTEIN, DANIEL, MACK, DAVID LEE · 2019 to 2023
$10.3M
Agence Nationale de la Recherche (ANR) ANR-21-CE11-0022-01American Heart Association (AHA) 22POST908934HHS | NIH | National Institute of General Medical Sciences (NIGMS) R01GM33289HHS | NIH | National Institute of General Medical Sciences (NIGMS) RM1GM131981-01NIGMS NIH HHS R01 GM033289NIGMS NIH HHS RM1 GM131981
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Cardiomyopathy, HypertrophicMutationAnimalsHumansMyocardial ContractionMyosinsMyosinsHypertrophic CardiomyopathyInteracting Heads MotifSuper-relaxed StateUnifying Hypothesisβ-Cardiac Myosin

Identifiers

PMID39192034
PMCPMC11445530

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.