Evidence map›Paper›PMID 39192009›Full record

ArticleAnnals of surgical oncology2024

Decision Regret in Patients with Appendiceal Cancer Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy.

Alexander Graves, Javid Sadjadi, Mikaela Kosich, Erin Ward, Divya Sood, Bridget Fahy, Shane Pankratz, Shiraz I Mishra, Alissa Greenbaum

Abstract read
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Article in Annals of surgical oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Long-term quality of life, financial toxicity, and decision regret following therapeutic and prophylactic gastrectomy for cancer.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2026
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alexander GravesSunrise Hospital and Medical Center, Las Vegas, NV, USA.
Javid SadjadiUniversity of New Mexico Comprehensive Cancer Center, Albuquerque, NM, USA.
Mikaela KosichUniversity of New Mexico Comprehensive Cancer Center, Albuquerque, NM, USA.
Erin WardHuntsman Cancer Institute, University of Utah Health, Salt Lake City, UT, USA.
Divya SoodOregon Health and Science University, Portland, OR, USA.
Bridget FahyUniversity of New Mexico Comprehensive Cancer Center, Albuquerque, NM, USA.
Shane PankratzUniversity of New Mexico Comprehensive Cancer Center, Albuquerque, NM, USA.
Shiraz I MishraUniversity of New Mexico Comprehensive Cancer Center, Albuquerque, NM, USA.
Alissa GreenbaumUniversity of New Mexico Comprehensive Cancer Center, Albuquerque, NM, USA. AGreenbaum@salud.unm.edu.ORCID http://orcid.org/0000-0003-2523-2919

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDecision regret is an emerging patient reported outcome. The aim of this study was to assess the incidence of regret in patients with appendiceal cancer (AC) who underwent cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC). PATIENTS AND

methodsAn anonymous survey was distributed to patients through the Appendix Cancer and Pseudomyxoma Peritonei (ACPMP) Research Foundation. The Decision Regret Scale (DRS) was employed, with DRS > 25 signifying regret. Patient demographics, tumor characteristics, postoperative outcomes, symptoms (FACT-C), and PROMIS-29 quality of life (QoL) scores were compared between patients who regretted or did not regret (NO-REG) the procedure.

resultsA total of 122 patients were analyzed. The vast majority had no regret about undergoing CRS-HIPEC (85.2%); 18 patients expressed regret (14.8%). Patients with higher regret had: income ≤ $74,062 (72.2% vs 44.2% NO-REG; p = 0.028), major complications within 30 days of surgery (55.6% vs 15.4% NO-REG; p < 0.001), > 30 days hospital stay (38.9% vs 4.8% NO-REG; p < 0.001), a new ostomy (27.8% vs 7.7% NO-REG; p = 0.03), >1 CRS-HIPEC procedure (56.3% vs 12.6% NO-REG; p < 0.001). Patients with worse FACT-C scores had more regret (p < 0.001). PROMIS-29 QOL scores were universally worse in patients with regret. Multivariable analysis demonstrated > 30 days in the hospital, new ostomy and worse gastrointestinal symptom scores were significantly associated with regret.

conclusionsThe majority of patients with AC undergoing CRS-HIPEC do not regret undergoing the procedure. Lower income, postoperative complications, an ostomy, undergoing > 1 procedure, and with worse long-term gastrointestinal symptoms were associated with increased regret. Targeted perioperative psychological support and symptom management may assist to ameliorate regret.

Indexed as

Appendiceal NeoplasmsCytoreduction Surgical ProceduresDecision MakingEmotionsHyperthermic Intraperitoneal ChemotherapyPeritoneal NeoplasmsQuality of LifeAdultAgedAntineoplastic Combined Chemotherapy ProtocolsChemotherapy, Cancer, Regional PerfusionCombined Modality TherapyFemaleFollow-Up StudiesHumansMaleAppendiceal cancerCytoreductive surgeryDecision regretHyperthermic intraperitoneal chemotherapyPseudomyxoma peritoneiQuality of life

Identifiers

PMID39192009

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.