Nitric oxide in the mechanisms of inhibitory effects of sodium butyrate on colon contractions in a mouse model of irritable bowel syndrome.

Ilnar Shaidullov, Djamila Bouchareb, Dina Sorokina, Guzel Sitdikova

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Article in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 authors.

Ilnar ShaidullovDepartment of Human and Animal Physiology, Institute of Fundamental Medicine and Biology, Kazan Federal University, 18, Kremlevskaya Str, 420008, Kazan, Russia. ilnarshaidullov@gmail.com.ORCID 0000-0001-9922-8010

Djamila BoucharebDepartment of Human and Animal Physiology, Institute of Fundamental Medicine and Biology, Kazan Federal University, 18, Kremlevskaya Str, 420008, Kazan, Russia.

Dina SorokinaDepartment of Human and Animal Physiology, Institute of Fundamental Medicine and Biology, Kazan Federal University, 18, Kremlevskaya Str, 420008, Kazan, Russia.ORCID 0000-0002-2114-6880

Guzel SitdikovaDepartment of Human and Animal Physiology, Institute of Fundamental Medicine and Biology, Kazan Federal University, 18, Kremlevskaya Str, 420008, Kazan, Russia.ORCID 0000-0001-5412-2204

Funding

Russian Science Foundation 23-75-01027

6 · The paper itself

Abstract

Irritable bowel syndrome (IBS) is a multifactorial disorder, with altered intestinal motility, visceral hypersensitivity, and dysfunction of the gut-brain axis. The aim of our study was to analyze the role of nitric oxide (NO) in the inhibitory effects of sodium butyrate on spontaneous contractility of proximal colon in a mouse model of IBS. IBS was induced by intracolonic infusion of acetic acid in the early postnatal period. Spontaneous contractions of proximal colon segments were studied in isometric conditions. The amplitude and frequency of colon contractions were higher in the IBS group. Sodium butyrate exerted inhibitory effects on colon contractions, which were less pronounced in IBS group. NO donors decreased spontaneous colon contractility and prevented the inhibitory effects of sodium butyrate in control and IBS groups. Nitric oxide synthase (NOS) inhibition by L-NAME increased contractile activity more effective in the control group and decreased the inhibitory action of sodium butyrate. In IBS group, preliminary application of L-NAME did not prevent sodium butyrate action. Our data indicate that butyrate exerts its inhibitory effects on colon motility at least partially through activation of NO synthesis. In the IBS model group, the NO-dependent mechanisms were less effective probably due to downregulation of NOS.

Indexed as

Butyric AcidColonIrritable Bowel SyndromeNitric OxideAcetic AcidAnimalsDisease Models, AnimalGastrointestinal MotilityMaleMiceMuscle ContractionNG-Nitroarginine Methyl EsterNitric Oxide SynthaseAcetic AcidButyric AcidNG-Nitroarginine Methyl EsterNitric OxideNitric Oxide SynthaseIrritable bowel syndromeMouse colon motilityNitric oxideShort chain fatty acidsSodium butyrate

Identifiers

PMID39191960

DOI10.1007/s00210-024-03403-1

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