Evidence map›Paper›PMID 39191951›Full record

ArticlePediatric research2025

Perinatal arterial ischemic stroke diagnosed in infants receiving therapeutic hypothermia for hypoxic-ischemic encephalopathy.

Fernando F Gonzalez, Sarah E Monsell, Marie-Coralie Cornet, Hannah Glass, Jessica Wisnowski, Amit Mathur, Robert McKinstry, Yi Li, Tai-Wei Wu, Dennis E Mayock and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Fernando F GonzalezDepartment of Pediatrics; UCSF Benioff Children's Hospital, University of California San Francisco, San Francisco, CA, USA. fernando.gonzalez@ucsf.edu.
Sarah E MonsellDepartment Biostatistics, University of Washington, Seattle, WA, USA.
Marie-Coralie CornetDepartment of Pediatrics; UCSF Benioff Children's Hospital, University of California San Francisco, San Francisco, CA, USA.
Hannah GlassDepartment of Neurology and Weill Institute for Neuroscience, University of California San Francisco, San Francisco, CA, USA.
Jessica WisnowskiDepartment of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Amit MathurDepartment of Pediatrics, Saint Louis University School of Medicine, St. Louis, MO, USA.
Robert McKinstryMallinckrodt Institute of Radiology, Washington Univ School of Medicine, St. Louis, MO, USA.
Yi LiDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA.
Tai-Wei WuDepartment of Pediatrics, Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.
Dennis E MayockDepartment of Pediatrics, Division of Neonatology, University of Washington School of Medicine, Seattle, WA, USA.
Patrick J HeagertyDepartment Biostatistics, University of Washington, Seattle, WA, USA.
Sandra E JuulDepartment of Pediatrics, Division of Neonatology, University of Washington School of Medicine, Seattle, WA, USA.
Yvonne W WuDepartment of Neurology and Weill Institute for Neuroscience, University of California San Francisco, San Francisco, CA, USA.

Funding

High-dose Erythropoietin for Asphyxia and Encephalopathy (HEAL) CCCU01NS092764 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JUUL, SANDRA E, WU, YVONNE W · 2016 to 2020
$12.7M
High-dose Erythropoietin for Asphyxia and Encephalopathy (HEAL) DCCU01NS092553 · NINDS · UNIVERSITY OF WASHINGTON · PI HEAGERTY, PATRICK J · 2016 to 2020
$1.7M
Validating MRS lipids as biomarkers of brain injury in neonates with hypoxic-ischemic encephalopathyK23HD099309 · NICHD · CHILDREN'S HOSPITAL OF LOS ANGELES · PI WISNOWSKI, JESSICA L · 2019 to 2023
$693k
NICHD NIH HHS K23 HD099309NINDS NIH HHS U01 NS092553NINDS NIH HHS U01 NS092764
6 · The paper itself

Abstract

backgroundBoth perinatal arterial ischemic stroke (PAIS) and hypoxic-ischemic encephalopathy (HIE) can present with neonatal encephalopathy. We hypothesized that among infants undergoing therapeutic hypothermia, presence of PAIS is associated with a higher risk of seizures and a lower risk of persistent encephalopathy after rewarming.

methodsWe studied 473 infants with moderate or severe HIE enrolled in the HEAL Trial who received a brain MRI. We defined PAIS as focal ischemic infarct(s) within an arterial distribution, and HIE pattern of brain injury as central gray, peripheral watershed, or global injury. We compared the risk of seizures (clinically suspected or electrographic), and of an abnormal 5-day Sarnat exam, in infants with and without PAIS.

resultsPAIS was diagnosed in 21(4%) infants, most of whom (16/21, 76%) also had concurrent HIE pattern of brain injury. Infants with PAIS were more likely to have seizures (RR 2.4, CI 2.8-3.3) and persistent moderate or severe encephalopathy on 5-day Sarnat exam (RR 2.5, 95% CI 1.9-3.4).

conclusionAmong infants undergoing therapeutic hypothermia, PAIS typically occurs with concurrent HIE pattern brain injury. The higher rate of encephalopathy after rewarming in infants with PAIS may be due to the frequent co-existence of PAIS and HIE patterns of injury.

Indexed as

Hypothermia, InducedHypoxia-Ischemia, BrainIschemic StrokeFemaleHumansInfantInfant, NewbornMagnetic Resonance ImagingMaleRisk FactorsSeizures

Identifiers

PMID39191951
PMCPMC12055579

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.