Trial reportScientific reports2024
The effect of intracanal cryotherapy with and without foraminal enlargement on pain prevention after endodontic treatment: a randomized clinical trial.
Trial report in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effectiveness of intracanal cryotherapy in reducing post-endodontic pain in irreversible pulpitis: a systematic review and meta-analysis.Scientific reports · 2026Pooled it
- Evaluation of postoperative pain associated with different working length determination methods: a randomised clinical study.BMC oral health · 2026Trial
- The effect of foraminal enlargement and irrigant activation technique on post-operative pain in necrotic teeth - a clinical study.BMC oral health · 2026Trial
- Evaluation of Post-Endodontic Pain Reduction Using Intracanal Cryotherapy in Symptomatic Apical Periodontitis.Australian endodontic journal : the journal of the Australian Society of Endodontology Inc · 2025Trial
- Postoperative Pain After Endodontic Treatment in HIV-Positive Patients Under HAART: A Prospective Observational Cohort Study.International endodontic journal · 2026Observational
- Effect of low-temperature intracanal sodium hypochlorite on root surface temperature reduction and organic tissue dissolution: an in vitro study.Scientific reports · 2026Article
- Post-operative pain in molar teeth with symptomatic apical periodontitis using cryotreated neem extract and cryotreated 2.5% sodium hypochlorite: A randomised double-blinded clinical trial.Bioinformation · 2026Article
- Comparative evaluation of antimicrobial-corticosteroid mixture and intracanal cryotherapy on post-instrumentation pain and microbial reduction: A randomized clinical trial.Journal of clinical and experimental dentistry · 2025Review
- A multivalent mRNA vaccine elicits robust immune responses and confers protection in a murine model of monkeypox virus infection.Nature communications · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This randomized clinical trial aims to evaluate cryotherapy as a therapeutic option for pain prevention after endodontic treatment with and without foraminal enlargement, in patients with asymptomatic apical periodontitis.120 teeth of patients with preoperative Visual Analogue Scale score indicating zero were treated. Specimens were randomly allocated into 4 groups: Control, Cryotherapy (ICT), Foraminal Enlargement (FE), and Cryotherapy and Foraminal Enlargement (ICT + FE). Working length was determined with an Electronic Apex Locator (EAL). Cryotherapy groups passed through a final irrigation protocol using 20 ml (2.5 ℃) of cold saline solution delivered at working length for 5 min. In FE groups a #40 K-file was used up to the 0.0 mark on the EAL display. Obturation was performed and postoperative pain was checked at 6, 12, 24, 48, and 72 h and 7 days after endodontic treatment.All experimental groups showed an increase in the level of postoperative pain, which started to decrease after 12 h. Foraminal enlargement caused a statistically significant increase in postoperativepain compared to ICT and control groups within the first 6 h (p < 0.05). Cryotherapy did not influence postoperative pain, regardless of whether or not foraminal enlargement was performed.
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