ArticleNature microbiology2024
Aspergillus fumigatus conidial surface-associated proteome reveals factors for fungal evasion and host immunity modulation.
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Article in Nature microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16citing papers in PubMed
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Who cites it
16 citing papers in PubMed.
- Subversion of Atypical Mucin Traps by a Spore-Coat Effector Blocks Cellular Immunity in Drosophila.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
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- Mixed-Pathogen Infections in Vegetatively Propagated Crops: From Biological Synergism to Integrated Management.Plants (Basel, Switzerland) · 2026Review
- Aspergillosis: An Update on Epidemiology, Risk Factors, Diagnosis, Susceptibility, and Treatment.Journal of fungi (Basel, Switzerland) · 2026Review
- Cell Surface Shaving-Based Proteomic Profiling of the Surfaceome in Pathogenic Microorganisms.International journal of molecular sciences · 2026Review
- Deglycosylation at War: Host N-Glycoprotein Remodeling in Infection and Immunity.Infection and drug resistance · 2026Review
- Single-cell analysis of human airway epithelium identifies cell-type-specific responses tomBio · 2025Article
- Spore-inspired inhalation drug delivery system for asthma therapy.Bioactive materials · 2025Article
- Article
- Aspergillus fumigatus biology, immunopathogenicity and drug resistance.Nature reviews. Microbiology · 2025Review
- Epidemiology, antifungal susceptibility and biological characteristics of clinical Aspergillus fumigatus in a tertiary hospital.Scientific reports · 2025Article
- Article
- Comparative Prognosis of Fungal Balls Versus Invasive Pulmonary Mucormycosis.Infection and drug resistance · 2025Article
- Metabolite analysis ofFrontiers in immunology · 2025Article
- Unveiling the fungal frontier: mycological insights into inflammatory bowel disease.Frontiers in immunology · 2025Review
- Worldwide trends and future projections of fungal skin disease burden: a comprehensive analysis from the Global Burden of Diseases study 2021.Frontiers in public health · 2025Observational
Corrections and comments
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Authors and funding
33 authors.
Camila Figueiredo Pinzan *Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil.
Clara Valero *Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil.
Patrícia Alves de CastroFaculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil.
Jefferson Luiz da SilvaFaculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil.
Kayleigh EarleManchester Fungal Infection Group, Division of Evolution, Infection, and Genomics, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Hong LiuDivision of Infectious Diseases, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Maria Augusta Crivelente HortaFaculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil.ORCID http://orcid.org/0000-0003-2159-5296
Olaf KniemeyerDepartment of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology (Leibniz-HKI) and Institute of Microbiology, Friedrich Schiller University, Jena, Germany.ORCID http://orcid.org/0000-0002-9493-6402
Thomas KrügerDepartment of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology (Leibniz-HKI) and Institute of Microbiology, Friedrich Schiller University, Jena, Germany.ORCID http://orcid.org/0000-0001-8984-3853
Annica PschibulDepartment of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology (Leibniz-HKI) and Institute of Microbiology, Friedrich Schiller University, Jena, Germany.
Derya Nur CömertDepartment of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology (Leibniz-HKI) and Institute of Microbiology, Friedrich Schiller University, Jena, Germany.
Thorsten HeinekampDepartment of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology (Leibniz-HKI) and Institute of Microbiology, Friedrich Schiller University, Jena, Germany.ORCID http://orcid.org/0000-0001-9503-9634
Axel A BrakhageDepartment of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology (Leibniz-HKI) and Institute of Microbiology, Friedrich Schiller University, Jena, Germany.ORCID http://orcid.org/0000-0002-8814-4193
Jacob L SteenwykHowards Hughes Medical Institute and the Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.
Matthew E MeadDepartment of Biological Sciences and Evolutionary Studies Initiative, Vanderbilt University, Nashville, TN, USA.
Nico HermsdorfDepartment of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology (Leibniz-HKI) and Institute of Microbiology, Friedrich Schiller University, Jena, Germany.
Scott G FillerDivision of Infectious Diseases, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Nathalia Gonsales da Rosa-GarzonFaculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil.
Endrews DelbajeFaculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil.ORCID http://orcid.org/0000-0002-0313-9046
Michael J BromleyManchester Fungal Infection Group, Division of Evolution, Infection, and Genomics, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.ORCID http://orcid.org/0000-0002-7611-0201
Hamilton CabralFaculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil.
Camila DiehlFaculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil.ORCID http://orcid.org/0000-0003-3174-0346
Claudia B AngeliDepartamento de Parasitologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-3906-1973
Giuseppe PalmisanoDepartamento de Parasitologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil.
Ashraf S IbrahimDivision of Infectious Diseases, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.ORCID http://orcid.org/0000-0003-3787-8530
David C RinkerDepartment of Biological Sciences and Evolutionary Studies Initiative, Vanderbilt University, Nashville, TN, USA.ORCID http://orcid.org/0000-0001-5894-7633
Thomas J C SautersDepartment of Biological Sciences and Evolutionary Studies Initiative, Vanderbilt University, Nashville, TN, USA.
Karin SteffenDepartment of Biological Sciences and Evolutionary Studies Initiative, Vanderbilt University, Nashville, TN, USA.ORCID http://orcid.org/0000-0003-0499-1430
Adiyantara GumilangDepartment of Biological Sciences and Evolutionary Studies Initiative, Vanderbilt University, Nashville, TN, USA.
Antonis RokasDepartment of Biological Sciences and Evolutionary Studies Initiative, Vanderbilt University, Nashville, TN, USA. antonis.rokas@vanderbilt.edu.ORCID http://orcid.org/0000-0002-7248-6551
Sara GagoManchester Fungal Infection Group, Division of Evolution, Infection, and Genomics, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. sara.gago-2@manchester.ac.uk.ORCID http://orcid.org/0000-0002-7027-4598
Thaila F Dos ReisFaculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil. thailaf@hotmail.com.ORCID http://orcid.org/0000-0002-7776-977X
Gustavo H GoldmanFaculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazil. ggoldman@usp.br.ORCID http://orcid.org/0000-0002-2986-350X
Funding
Deciphering the phenotypic and genomic traits that underlie the evolution of pathogenicity differences among Aspergillus fumigatus and its close relativesR01AI153356 · NIAID · VANDERBILT UNIVERSITY · PI Antonis Rokas · 2022 to 2026
$3.5MTranscriptional networks governing A. fumigatus virulenceR01AI162802 · NIAID · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI FILLER, SCOTT G, MOYE-ROWLEY, W SCOTT · 2021 to 2025
$3.3MTranscriptional regulation of A. fumigatus virulenceR01AI073829 · NIAID · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI FILLER, SCOTT G · 2007 to 2015
$2.8MNational Centre for the Replacement, Refinement and Reduction of Animals in Research NC/T001798/1NIAID NIH HHS R01 AI073829NIAID NIH HHS R01 AI153356NIAID NIH HHS R01 AI162802Wellcome Trust
Abstract
Aspergillus fumigatus causes aspergillosis and relies on asexual spores (conidia) for initiating host infection. There is scarce information about A. fumigatus proteins involved in fungal evasion and host immunity modulation. Here we analysed the conidial surface proteome of A. fumigatus, two closely related non-pathogenic species, Aspergillus fischeri and Aspergillus oerlinghausenensis, as well as pathogenic Aspergillus lentulus, to identify such proteins. After identifying 62 proteins exclusively detected on the A. fumigatus conidial surface, we assessed null mutants for 42 genes encoding these proteins. Deletion of 33 of these genes altered susceptibility to macrophage, epithelial cells and cytokine production. Notably, a gene that encodes a putative glycosylasparaginase, modulating levels of the host proinflammatory cytokine IL-1β, is important for infection in an immunocompetent murine model of fungal disease. These results suggest that A. fumigatus conidial surface proteins are important for evasion and modulation of the immune response at the onset of fungal infection.
Indexed as
AspergillosisAspergillus fumigatusFungal ProteinsImmune EvasionProteomeSpores, FungalAnimalsCytokinesDisease Models, AnimalEpithelial CellsFemaleHost-Pathogen InteractionsHumansMacrophagesMembrane ProteinsMiceCytokinesFungal ProteinsMembrane ProteinsProteome
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