Evidence map›Paper›PMID 39191880›Full record

ArticleScientific reports2024

In vitro analysis of a novel dimethylaminododecyl methacrylate modification of dental acrylic soft liner material.

Mohamed M Ammar, Hala A Elkammar, Abdelfattah A Abdelkhalek, Nada A Abdelrazek, Ahmed A Emam, Bassem M Abdelhameed

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In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mohamed M AmmarBiomaterials Department, Faculty of Oral and Dental Medicine, Future University in Egypt, New Cairo, 11865, Egypt.
Hala A ElkammarOral Pathology Department, Faculty of Oral and Dental Medicine, Future University in Egypt, New Cairo, 11865, Egypt. hala.ahmed@fue.edu.eg.
Abdelfattah A AbdelkhalekMicrobiology Department of Supplementary General Science, Faculty of Oral and Dental Medicine, Future University in Egypt, New Cairo, 11865, Egypt.
Nada A AbdelrazekMicrobiology and Immunology Department, Faculty of Pharmacy, Future University in Egypt, New Cairo, 11865, Egypt.
Ahmed A EmamMedical Experimental Research Center (MERC), Faculty of Medicine, Mansoura University, Mansoura, 35511, Egypt.
Bassem M AbdelhameedRemovable Prosthodontic Department, Faculty of Oral and Dental Medicine, Future University in Egypt, New Cairo, 11865, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Soft denture liners have limitations like short lifespan and increased microbial buildup. Despite promise as a non-leaching antimicrobial polymer in dentistry, the impact of dimethylaminododecyl methacrylate (DMADDM) on soft liner performance remains unexplored. This study aimed to evaluate the effect of integrating different concentrations of DMADDM to cold cure acrylic resin soft liner, on its antimicrobial activity, cytotoxicity, and physical properties. The same properties were compared to a conventional commercially available denture soft liner. The study employed a control group (conventional soft liner) and three test groups containing 3.3%, 6.6%, and 10% (total mass fraction) DMADDM, respectively. Antimicrobial activity against Candida albicans and Streptococcus mutans was assessed through colony counts and biofilm biomass. Cytotoxicity was evaluated using an oral epithelial cell line. Additionally, wettability and hardness were measured to assess physical properties. Incorporation of DMADDM significantly reduced Candida albicans and Streptococcus mutans counts, and biofilm biomass, compared to the control. Additionally, DMADDM improved the soft liner's wettability and mitigated long-term hardness increase. In conclusion, DMADDM holds promise in enhancing soft liner performance. However, careful selection of its optimum concentration is crucial to ensure both safety and efficacy for future clinical use.

Indexed as

BiofilmsCandida albicansMethacrylatesStreptococcus mutansAcrylic ResinsAnti-Infective AgentsCell LineDental MaterialsDenture LinersHumansMaterials TestingQuaternary Ammonium CompoundsAcrylic ResinsAnti-Infective AgentsDental Materialsdimethylaminododecyl methacrylateMethacrylatesQuaternary Ammonium CompoundsBiofilmCytotoxicityDimethylaminododecyl methacrylateHardnessSoft liner

Identifiers

PMID39191880
PMCPMC11349986

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.