Evidence map›Paper›PMID 39191850›Full record

ArticleScientific reports2024

Pharmacological investigation of new niclosamide-based isatin hybrids as antiproliferative, antioxidant, and apoptosis inducers.

Mervat M Omran, Mona M Kamal, Yousry A Ammar, Moustafa S Abusaif, Magda M F Ismail, Heba H Mansour

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mervat M OmranPharmacology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt.ORCID 0000-0003-1643-0104
Mona M KamalPharmacology and Toxicology Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.ORCID 0000-0002-5986-5012
Yousry A AmmarDepartment of Chemistry, Faculty of Science (Boys), Al-Azhar University, Nasr City, Cairo, 11884, Egypt.
Moustafa S AbusaifDepartment of Chemistry, Faculty of Science (Boys), Al-Azhar University, Nasr City, Cairo, 11884, Egypt.
Magda M F IsmailDepartment of Medicinal Pharmaceutical Chemistry and Drug Design, Faculty of Pharmacy (Girls), Al-Azhar University, Nasr City, Cairo, 11754, Egypt.ORCID 0000-0002-3915-9786
Heba H MansourHealth Radiation Research Department, National Centre for Radiation Research and Technology, Egyptian Atomic Energy Authority, P.O. Box 29, Nasr City Cairo, Egypt. hebahosny@hotmail.com.ORCID 0000-0002-6417-7468

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A group of Niclosamide-linked isatin hybrids (Xo, X1, and X2) was created and examined using IR,

Indexed as

Antineoplastic AgentsAntioxidantsApoptosisCell ProliferationIsatinMolecular Docking SimulationNiclosamideAnimalsCell Line, TumorChlorocebus aethiopsHCT116 CellsHep G2 CellsHumansMCF-7 CellsMembrane Potential, MitochondrialReactive Oxygen SpeciesAntineoplastic AgentsAntioxidantsIsatinNiclosamideReactive Oxygen SpeciesAntioxidantApoptosisCell cycleCytotoxicityMolecular dockingNiclosamide analogue synthesis

Identifiers

PMID39191850
PMCPMC11349906

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.