Evidence map›Paper›PMID 39191763›Full record

ArticleNPJ vaccines2024

Neutralizing and binding antibody responses to SARS-CoV-2 with hybrid immunity in pregnancy.

Lin Li, Yusuke Matsui, Mary K Prahl, Arianna G Cassidy, Yarden Golan, Unurzul Jigmeddagva, Nida Ozarslan, Christine Y Lin, Sirirak Buarpung, Veronica J Gonzalez and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ vaccines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Lin Li *Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-8974-4636
Yusuke Matsui *Gladstone Institute of Virology, San Francisco, CA, USA.
Mary K PrahlDepartment of Pediatrics, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-0091-2731
Arianna G CassidyDivision of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA.
Yarden GolanDepartment of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA.
Unurzul JigmeddagvaDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Center for Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA.
Nida OzarslanDivision of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-3235-1238
Christine Y LinDivision of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA.
Sirirak BuarpungDivision of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA.
Veronica J GonzalezDivision of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA.
Megan A ChidboyDivision of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA.
Emilia BasilioDivision of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA.
Kara L LynchDepartment of Laboratory Medicine, University of California San Francisco, San Francisco, CA, USA.
Dongli SongDivision of Neonatology, Department of Pediatrics, Santa Clara Valley Medical Center, San Jose, CA, USA.
Priya JegatheesanDivision of Neonatology, Department of Pediatrics, Santa Clara Valley Medical Center, San Jose, CA, USA.
Daljeet S RaiStanford-O'Connor Family Medicine Residency Program, Division of Family Medicine, Stanford University, Palo Alto, CA, USA.
Balaji GovindaswamiDivision of Neonatology, Department of Pediatrics, Marshall University Joan C Edwards School of Medicine, Huntington, WV, USA.
Jordan NeedensDepartment of Obstetrics and Gynecology, Marshall University Joan C Edwards School of Medicine, Huntington, WV, USA.
Monica RinconDepartment of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR, USA.ORCID http://orcid.org/0000-0001-5574-585X
Leslie MyattDepartment of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR, USA.
Taha Y TahaGladstone Institute of Virology, San Francisco, CA, USA.
Mauricio MontanoGladstone Institute of Virology, San Francisco, CA, USA.
Melanie OttGladstone Institute of Virology, San Francisco, CA, USA.
Warner C GreeneGladstone Institute of Virology, San Francisco, CA, USA. warner.greene@gladstone.ucsf.edu.
Stephanie L GawDivision of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA. stephanie.gaw@ucsf.edu.ORCID http://orcid.org/0000-0003-0891-6964

Funding

Investigating the role of maternal-fetal crosstalk on neonatal immunity in COVID-19 infection or vaccination in pregnancyR01HD111582 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Stephanie Lina Gaw · 2023 to 2026
$2.8M
Determinants of Early Childhood Immune Responses to SARS-CoV-2 VaccinationR01HD112339 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Mary Prahl · 2023 to 2026
$2.7M
The Immunologic Impact of In Utero Malaria Exposure and Prenatal ChemopreventionK23AI127886 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PRAHL, MARY · 2017 to 2021
$1.0M
Placental malaria: The role of inflammation at the maternal-fetal interfaceK08AI141728 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GAW, STEPHANIE LINA · 2019 to 2023
$950k
NIAID NIH HHS K08 AI141728NIAID NIH HHS K23 AI127886NICHD NIH HHS R01 HD111582NICHD NIH HHS R01 HD112339U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) R01HD111582U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) R01HD112339U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) K08AI141728U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) K23AI127886
6 · The paper itself

Abstract

Hybrid immunity against SARS-CoV-2 has not been well studied in pregnancy. We conducted a comprehensive analysis of neutralizing antibodies (nAb) and binding antibodies in pregnant individuals who received mRNA vaccination, natural infection, or both. A third vaccine dose augmented nAb levels compared to the two-dose regimen or natural infection alone; this effect was more pronounced in hybrid immunity. There was reduced anti-Omicron nAb, but the maternal-fetal transfer efficiency remained comparable to that of other variants. Vaccine-induced nAbs were transferred more efficiently than infection-induced nAbs. Anti-spike receptor binding domain (RBD) IgG was associated with nAb against wild-type (Wuhan-Hu-1) following breakthrough infection. Both vaccination and infection-induced anti-RBD IgA, which was more durable than anti-nucleocapsid IgA. IgA response was attenuated in pregnancy compared to non-pregnant controls. These data provide additional evidence of augmentation of humoral immune responses in hybrid immunity in pregnancy.

Identifiers

PMID39191763
PMCPMC11349990

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.