Evidence map›Paper›PMID 39191278›Full record

ArticleOpen biology2024

Molecular basis of urostyle development in frogs: genes and gene regulation underlying an evolutionary novelty.

Gayani Senevirathne, Neil H Shubin

Abstract read
In one paragraph

Article in Open biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Gayani SenevirathneHuman Evolutionary Biology, Harvard University , Cambridge, MA 02138, USA.ORCID 0000-0001-6704-9691
Neil H ShubinOrganismal Biology and Anatomy, University of Chicago Biological Sciences Division , Chicago, IL 60637, USA.

Funding

Brinson Foundation
6 · The paper itself

Abstract

Evolutionary novelties entail the origin of morphologies that enable new functions. These features can arise through changes to gene function and regulation. One key novelty is the fused rod at the end of the vertebral column in anurans, the urostyle. This feature is composed of a coccyx and a hypochord, both of which ossify during metamorphosis. To elucidate the genetic basis of these features, we used laser capture microdissection of these tissues and did RNA-seq and ATAC-seq at three developmental stages in tadpoles of

Indexed as

Gene Expression Regulation, DevelopmentalAnimalsBiological EvolutionCoccyxGene Expression ProfilingLarvaMetamorphosis, BiologicalOsteogenesisSpineTranscriptomeXenopusXenopus ProteinsXenopus ProteinsATAC-seqhypochordmetamorphosisRNA-seqT-box genes

Identifiers

PMID39191278
PMCPMC11349433

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.