Evidence map›Paper›PMID 39191219›Full record

ArticleCells, tissues, organs2024

Reconsidering Neurogenetic Indication in the Human Brain: Broad Expression of Doublecortin Transcript in the Hippocampal and Cortical Cell Populations.

Tae-Hyeon Cho, Miri Kim, Shin Hyung Kim, Jong Eun Lee, Se Hoon Kim, Hyun Jung Kim, Ju-Eun Hong, In-Seung Yeo, Hun-Mu Yang

Abstract read
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Article in Cells, tissues, organs, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Tae-Hyeon ChoDepartment of Anatomy, College of Korean Medicine, Semyung University, Jecheon, Republic of Korea.
Miri KimTranslational Research Unit for Anatomy and Analgesia, Seoul, Republic of Korea.
Shin Hyung KimTranslational Research Unit for Anatomy and Analgesia, Seoul, Republic of Korea.
Jong Eun LeeDepartment of Anatomy, Yonsei University College of Medicine, Seoul, Republic of Korea.
Se Hoon KimDepartment of Pathology, Yonsei University College of Medicine, Seoul, Republic of Korea.
Hyun Jung KimDepartment of Anatomy, College of Medicine, Korea University, Seoul, Republic of Korea.
Ju-Eun HongDepartment of Biomedical Laboratory Science, College of Software and Digital Healthcare Convergence, Yonsei University MIRAE Campus, Wonju, Republic of Korea.
In-Seung YeoTranslational Research Unit for Anatomy and Analgesia, Seoul, Republic of Korea.
Hun-Mu YangTranslational Research Unit for Anatomy and Analgesia, Seoul, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionNeurogenesis in the adult brain may play an important role in memory and cognition; however, knowledge of neurogenic markers in the human brain remains limited. We compared the single-nucleus transcriptome of the hippocampus with that of other cortical regions to identify hippocampus-specific neurogenic markers.

methodsWe analyzed 26,189 nuclei from four human brains collected within 16 h of death. Clustering and annotation were performed to examine differential expression, gene ontology, and intercellular communication. DCX expression was validated by ddPCR.

resultsImmature markers such as DCX, CALB2, NES, SOX2, PAX6, DPYSL3, and TUBB3 were expressed in both hippocampus and prefrontal cortex, with higher levels in the prefrontal cortex. ddPCR confirmed higher expression of DCX in the prefrontal cortex. DCX was involved in both neurogenesis and neuroprotection pathways.

conclusionNeurogenic markers are not definitive indicators of adult neurogenesis as their roles are more complex than previously understood.

Indexed as

Doublecortin ProteinHippocampusNeurogenesisAdultCerebral CortexDoublecortin Domain ProteinsFemaleHumansMaleMicrotubule-Associated ProteinsNeuropeptidesTranscriptomeDCX protein, humanDoublecortin Domain ProteinsDoublecortin ProteinMicrotubule-Associated ProteinsNeuropeptidesAdult neurogenesisDegenerative diseaseHippocampusNeural stem cellPrefrontal cortexSingle-nucleus RNA sequencing

Identifiers

PMID39191219
PMCPMC11446342

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.