Evidence map›Paper›PMID 39190892›Full record

SynthesisNutrition reviews2025

Impact of Diet Modifications on Body Weight, Body Composition, Treatment Outcomes, and Quality of Life During Primary Treatment for Breast Cancer: A Systematic Review.

Kaitlin Chakos, Lacey Pezley, Alyssa Bryner, Ola Czyzewski, Jennifer Corral, Vanessa Marquina, Vijayakrishna Gadi, Pamela Ganschow, Lisa Tussing-Humphreys, Kelsey Gabel

Abstract readSystematic Review
In one paragraph

Synthesis in Nutrition reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kaitlin ChakosDepartment of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, IL 60612, United States.ORCID 0009-0001-0887-4277
Lacey PezleyDepartment of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, IL 60612, United States.ORCID 0000-0003-3385-8460
Alyssa BrynerDepartment of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, IL 60612, United States.
Ola CzyzewskiDepartment of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, IL 60612, United States.
Jennifer CorralDepartment of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, IL 60612, United States.
Vanessa MarquinaDepartment of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, IL 60612, United States.
Vijayakrishna GadiDepartment of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, IL 60612, United States.
Pamela GanschowDepartment of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, IL 60612, United States.
Lisa Tussing-HumphreysDepartment of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, IL 60612, United States.
Kelsey GabelDepartment of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, IL 60612, United States.ORCID 0000-0003-4613-8892

Funding

Mediterranean Diet and Weight Loss: Targeting the Bile Acid/Gut Microbiome Axis to Reduce Colorectal Cancer RiskR01CA250390 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI FITZGIBBON, MARIAN L., TUSSING-HUMPHREYS, LISA · 2021 to 2025
$3.1M
UIC Building Interdisciplinary Research Careers in Women's Health ProgramK12AR084225 · NIAMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI IRINA A BUHIMSCHI, PAULINE M MAKI · 2023 to 2026
$3.0M
UIC Building Interdisciplinary Research Careers in Women's Health ProgramK12HD101373 · NICHD · UNIVERSITY OF ILLINOIS AT CHICAGO · PI BUHIMSCHI, IRINA A, MAKI, PAULINE M · 2020 to 2023
$2.9M
Diet modulation of bacterial sulfur & bile acid metabolism and colon cancer riskR01CA204808 · NCI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI GASKINS, REX, MUTLU, ECE A. · 2016 to 2020
$2.0M
NCI NIH HHS L30 CA295383NCI NIH HHS R01 CA204808NCI NIH HHS R01 CA250390NIAMS NIH HHS K12 AR084225NICHD NIH HHS K12 HD101373NIH HHS R01CA250390
6 · The paper itself

Abstract

contextBreast cancer is a significant public health challenge, with 290 000 new cases annually and significant healthcare costs. Treatment advancements have led to improvements in survival, but common adverse effects include weight gain, fatigue, nausea, and taste changes, decreasing quality of life.

objectiveThis review aims to assess the impact of diet and lifestyle interventions during primary treatment for breast cancer and their effects on body weight, body composition, treatment-related adverse outcomes, and patient-reported quality of life. DATA SOURCES AND DATA EXTRACTION: A search of PubMed, CINAHL, and EMBASE conducted through May 10, 2023, identified 31 publications describing 27 interventions including diet or diet plus exercise. The Cochrane Risk of Bias tool assessed the quality of publications. DATA ANALYSIS: The findings suggest that whole foods, aerobic and strength-training exercises, and intermittent fasting during treatment may improve body weight and composition, treatment-related outcomes, and quality of life. Limitations include variation in study duration, small sample sizes, and limited sociodemographic data.

conclusionImprovements seen with increased diet quality and reduced caloric intake, with or without exercise, challenge current standard-of-care recommendations during treatment for breast cancer. While there is a need for additional research, healthcare teams can confidently promote healthy diets and exercise during primary treatment for breast cancer to manage weight and improve treatment-related side effects and quality of life. SYSTEMATIC REVIEW REGISTRATION: PROSPERO registration no. 42023425613.

Indexed as

Body CompositionBody WeightBreast NeoplasmsDietQuality of LifeExerciseFemaleHumansLife StyleTreatment Outcomeantineoplastic protocolsbreast cancerdietdiet therapynutritional interventiontreatment

Identifiers

PMID39190892
PMCPMC11819483

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.