Evidence map›Paper›PMID 39190867›Full record

ReviewACS biomaterials science & engineering2024

Engineered Biomaterials and Model Systems to Study YAP/TAZ in Cancer.

Emma Villares, Sharon Gerecht

Abstract readReview
In one paragraph

Review in ACS biomaterials science & engineering, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Emma VillaresDepartment of Biomedical Engineering, Duke University, Durham, North Carolina 27705, United States.
Sharon GerechtDepartment of Biomedical Engineering, Duke University, Durham, North Carolina 27705, United States.ORCID 0000-0002-8542-4835

Funding

University Training Program in Biomolecular and Tissue EngineeringT32GM144291 · NIGMS · DUKE UNIVERSITY · PI Charles A. Gersbach, Tatiana Segura · 2022 to 2026
$2.6M
NIGMS NIH HHS T32 GM144291
6 · The paper itself

Abstract

The transcriptional coactivators yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) are master regulators involved in a multitude of cancer types and a wide range of tumorigenic events, including cancer stem cell renewal, invasion, metastasis, tumor precursor emergence, and drug resistance. YAP/TAZ are known to be regulated by several external cues and stimuli, such as extracellular matrix stiffness, cell spreading, cell geometry, and shear stress. Therefore, there is a need in the field of cancer research to develop and design relevant

Indexed as

Biocompatible MaterialsNeoplasmsTranscription FactorsAdaptor Proteins, Signal TransducingAnimalsHumansHydrogelsModels, BiologicalTrans-ActivatorsTranscriptional Coactivator with PDZ-Binding Motif ProteinsTumor MicroenvironmentYAP-Signaling ProteinsAdaptor Proteins, Signal TransducingBiocompatible MaterialsHydrogelsTrans-ActivatorsTranscriptional Coactivator with PDZ-Binding Motif ProteinsTranscription FactorsWWTR1 protein, humanYAP1 protein, humanYAP-Signaling Proteinshydrogelmatrix stiffnessmicrofluidicsorganoid

Identifiers

PMID39190867
PMCPMC13676292

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.