Observational studyJournal of the American Heart Association2024
Cerebrovascular Events in Patients Undergoing Transfemoral Transcatheter Aortic Valve Implantation: A Pooled Patient-Level Study.
Observational study in Journal of the American Heart Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03588247 (Cerebrovascular EveNts in Patients Undergoing TranscathetER Aortic Valve Implantation With Balloon-expandable Valves Versus Self-expandable Valves.), which is not on this map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cerebrovascular EveNts in Patients Undergoing TranscathetER Aortic Valve Implantation With Balloon-expandable Valves Versus Self-expandable Valves.
Who cites it
16 citing papers in PubMed.
- Differential Predictors of Early and Mid-to-Long Term Cerebrovascular Events Following Transcatheter Aortic Valve Implantation.Medicina (Kaunas, Lithuania) · 2026Observational
- Pre-Existing and New-Onset Atrial Fibrillation in Patients Undergoing Transcatheter Aortic Valve Implantation.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2026Article
- Cerebral embolic protection (CEP) during transcatheter aortic valve replacement (TAVR) is associated with a lower rate of stroke at a high-volume center.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Comparison of the Self-Expandable Intra-Annular Navitor Prosthesis with the Balloon-Expandable, Intra-Annular Sapien 3 Prosthesis: A Propensity-Matched Analysis.Journal of clinical medicine · 2026Article
- Stroke Rates and Clinical Outcomes After Transcaval Transcatheter Aortic Valve Replacement With and Without Central Embolic Protection: A Single-Center Experience.Journal of the Society for Cardiovascular Angiography & Interventions · 2026Article
- Different Types of Aortic Valve Stenosis in Patients Undergoing Transcatheter Aortic Valve Replacement.Structural heart : the journal of the Heart Team · 2026Article
- The Utility of Cerebral Protection Devices in Transcatheter Aortic Valve Replacement: A Systematic Review and Bayesian Meta-analysis.Journal of the Society for Cardiovascular Angiography & Interventions · 2026Review
- Stroke in Transcatheter Aortic Valve Implantation (TAVI): A Comprehensive Review.Journal of clinical medicine · 2025Review
- A Novel Approach for Cerebral Embolic Protection With Single-Artery Access in TAVR.JACC. Case reports · 2025Article
- Preventing cerebrovascular events in patients undergoing TAVR: the current and future landscape.Future cardiology · 2025Article
- What Are SAVR Indications in the TAVI Era?Journal of clinical medicine · 2025Review
- Cerebral blood flow and cognitive functioning in patients undergoing transcatheter aortic valve implantation.EClinicalMedicine · 2025Article
- Protruding and Ulcerated Aortic Atheromas as Predictors of Periprocedural Ischemic Stroke Post-Transcatheter Aortic Valve Replacement.JACC. Asia · 2025Article
- 2024 Update on Cerebral Embolic Protection After Transcatheter Aortic Valve Replacement.Journal of clinical medicine · 2024Review
- Article
- Stroke in Patients Undergoing Transcatheter Aortic Valve Replacement: Embracing the Unpredictable.Journal of the American Heart Association · 2024Article
Corrections and comments
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Authors and funding
24 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCerebrovascular events remain one of the most devastating complications of transcatheter aortic valve implantation (TAVI). Data from real-world contemporary cohorts on longitudinal trends and outcomes remain limited. The aim of this study was to assess incidence, temporal trends, predictors, and outcomes of cerebrovascular events following transfemoral TAVI. METHODS AND
resultsThe CENTER2 (Cerebrovascular Events in Patients Undergoing Transcatheter Aortic Valve Implantation With Balloon-Expandable Valves Versus Self-Expandable Valves 2) study includes patients undergoing TAVI between 2007 and 2022. The database contains pooled patient-level data from 10 clinical studies. A total of 24 305 patients underwent transfemoral TAVI (mean age 81.5±6.7 years, 56% women, median Society of Thoracic Surgeon Predicted Risk of Mortality 4.9% [3.1%-8.5%]). Of these patients, 2.2% (n=534) experienced stroke in the first 30 days after TAVI, and 40 (0.4%) had a transient ischemic attack. Stroke rates remained stable during the treatment period (2007-2010: 2.1%, 2011-2014: 2.5%, 2015-2018: 2.1%, 2019-2022: 2.1%;
conclusionsIn 24 305 patients who underwent transfemoral TAVI, 30-day cerebrovascular event incidence remained ≈ 2.2% between 2007 and 2022. Thirty-day stroke rates were similar throughout Society of Thoracic Surgeon Predicted Risk of Mortality risk categories. Mortality rates after stroke remain high. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT03588247.
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