Evidence map›Paper›PMID 39190578›Full record

SynthesisJournal of the American Heart Association2024

Residual Stroke Risk Among Patients With Atrial Fibrillation Prescribed Oral Anticoagulants: A Patient-Level Meta-Analysis From COMBINE AF.

Linda S Johnson, Alexander P Benz, Ashkan Shoamanesh, John W Eikelboom, Michael Ezekowitz, Robert P Giugliano, Lars Wallentin, Christian T Ruff, Renato D Lopes, Sanjit Jolly and 4 more

Abstract readMeta-Analysis
In one paragraph

Synthesis in Journal of the American Heart Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2026
    Article
  5. Observational
  6. Article
  7. Article
  8. Cardiac thrombus despite anticoagulation in a 76-year-old man.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2025
    Article
  9. Observational
  10. Article
  11. CHAFrontiers in cardiovascular medicine · 2025
    Article
  12. Journal of the American Heart Association · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Linda S JohnsonPopulation Health Research Institute, McMaster University Hamilton Canada.ORCID 0000-0002-2249-8220
Alexander P BenzPopulation Health Research Institute, McMaster University Hamilton Canada.ORCID 0000-0003-2555-1266
Ashkan ShoamaneshPopulation Health Research Institute, McMaster University Hamilton Canada.ORCID 0000-0002-2802-1626
John W EikelboomPopulation Health Research Institute, McMaster University Hamilton Canada.ORCID 0000-0003-4126-1285
Michael EzekowitzSydney Kimmel Medical School Thomas Jefferson University Philadelphia PA USA.ORCID 0000-0003-3623-2252
Robert P GiuglianoDivision of Cardiovascular Medicine Brigham and Women's Hospital, Harvard Medical School Boston MA USA.ORCID 0000-0003-4110-7675
Lars WallentinUppsala Clinical Research Centre Uppsala University Uppsala Sweden.ORCID 0000-0003-0378-6531
Christian T RuffDivision of Cardiovascular Medicine Brigham and Women's Hospital, Harvard Medical School Boston MA USA.ORCID 0000-0002-4712-3206
Renato D LopesDepartment of Medical Sciences, Cardiology Uppsala University Uppsala Sweden.ORCID 0000-0003-2999-4961
Sanjit JollyPopulation Health Research Institute, McMaster University Hamilton Canada.ORCID 0000-0003-2329-2504
Richard WhitlockPopulation Health Research Institute, McMaster University Hamilton Canada.ORCID 0000-0002-6863-5884
Christopher B GrangerDivision of Cardiology Duke University Durham NC USA.ORCID 0000-0002-0045-3291
Stuart ConnollyPopulation Health Research Institute, McMaster University Hamilton Canada.ORCID 0000-0002-7377-335X
Jeffrey S HealeyPopulation Health Research Institute, McMaster University Hamilton Canada.ORCID 0000-0003-1216-7580

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDespite oral anticoagulation, patients with atrial fibrillation (AF) remain at risk of ischemic stroke and systemic embolism (SE) events. For patients whose residual risk is sufficiently high, additional therapies might be useful to mitigate stroke risk. METHODS AND

resultsIndividual patient data from 5 landmark trials testing oral anticoagulation in AF were pooled in A Collaboration Between Multiple Institutions to Better Investigate Non-Vitamin K Antagonist Oral Anticoagulant Use in AF (COMBINE AF). We calculated the rate of ischemic stroke/SE among oral anticoagulation-treated patients with a CHA

conclusionsAF type, CHA

Indexed as

AnticoagulantsAtrial FibrillationAdministration, OralAgedAged, 80 and overFemaleHumansIschemic StrokeMaleMiddle AgedRandomized Controlled Trials as TopicRisk AssessmentRisk FactorsAnticoagulantsanticoagulationatrial fibrillationstroke

Identifiers

PMID39190578
PMCPMC11646504

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.