Evidence map›Paper›PMID 39190548›Full record

ArticleJournal of medicinal chemistry2024

Selective Aurora A-TPX2 Interaction Inhibitors Have

Simon R Stockwell, Duncan E Scott, Gerhard Fischer, Estrella Guarino, Timothy P C Rooney, Tzu-Shean Feng, Tommaso Moschetti, Rajavel Srinivasan, Esther Alza, Alice Asteian and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Unveiling the Diagnostic Value and Potential Therapeutic Targets of Phenylalanine Metabolism in Pancreatic Cancer via Integrated Multi-Omics and Machine Learning.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. An insight into theFuture medicinal chemistry · 2025
    Review
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Simon R StockwellMedical Research Council Cancer Unit, University of Cambridge, Cambridge CB2 0XZ, U.K.
Duncan E ScottYusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K.
Gerhard FischerDepartment of Biochemistry, University of Cambridge, Cambridge CB2 1GA, U.K.
Estrella GuarinoMedical Research Council Cancer Unit, University of Cambridge, Cambridge CB2 0XZ, U.K.
Timothy P C RooneyYusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K.ORCID 0000-0001-6788-5526
Tzu-Shean FengYusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K.
Tommaso MoschettiDepartment of Biochemistry, University of Cambridge, Cambridge CB2 1GA, U.K.
Rajavel SrinivasanYusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K.
Esther AlzaYusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K.
Alice AsteianYusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K.
Claudio DagostinYusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K.
Anna AlcaideYusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K.
Mathieu RocaboyDepartment of Biochemistry, University of Cambridge, Cambridge CB2 1GA, U.K.
Beata BlaszczykDepartment of Biochemistry, University of Cambridge, Cambridge CB2 1GA, U.K.
Alicia HiguerueloDepartment of Biochemistry, University of Cambridge, Cambridge CB2 1GA, U.K.
Xuelu WangDepartment of Biochemistry, University of Cambridge, Cambridge CB2 1GA, U.K.
Maxim RossmannDepartment of Biochemistry, University of Cambridge, Cambridge CB2 1GA, U.K.
Trevor R Perrior
Tom L BlundellDepartment of Biochemistry, University of Cambridge, Cambridge CB2 1GA, U.K.
David R SpringYusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K.
Grahame McKenzieMedical Research Council Cancer Unit, University of Cambridge, Cambridge CB2 0XZ, U.K.
Chris AbellYusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K.ORCID 0000-0001-9174-1987
John SkidmoreYusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K.ORCID 0000-0001-9108-7858
Ashok R VenkitaramanMedical Research Council Cancer Unit, University of Cambridge, Cambridge CB2 0XZ, U.K.
Marko HyvönenDepartment of Biochemistry, University of Cambridge, Cambridge CB2 1GA, U.K.ORCID 0000-0001-8683-4070

Funding

Wellcome Trust
6 · The paper itself

Abstract

Aurora A kinase, a cell division regulator, is frequently overexpressed in various cancers, provoking genome instability and resistance to antimitotic chemotherapy. Localization and enzymatic activity of Aurora A are regulated by its interaction with the spindle assembly factor TPX2. We have used fragment-based, structure-guided lead discovery to develop small molecule inhibitors of the Aurora A-TPX2 protein-protein interaction (PPI). Our lead compound,

Indexed as

Antimitotic AgentsAurora Kinase ACell Cycle ProteinsMicrotubule-Associated ProteinsAnimalsAntineoplastic AgentsCell Line, TumorHumansMiceMice, NudeNuclear ProteinsPaclitaxelProtein Kinase InhibitorsStructure-Activity RelationshipXenograft Model Antitumor AssaysAntimitotic AgentsAntineoplastic AgentsAurora Kinase ACell Cycle ProteinsMicrotubule-Associated ProteinsNuclear ProteinsPaclitaxelProtein Kinase InhibitorsTPX2 protein, human

Identifiers

PMID39190548
PMCPMC11403621

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.