Evidence map›Paper›PMID 39190506›Full record

ReviewIUCrJ2024

Structural characterization of TIR-domain signalosomes through a combination of structural biology approaches.

Akansha Bhatt, Biswa P Mishra, Weixi Gu, Mitchell Sorbello, Hongyi Xu, Thomas Ve, Bostjan Kobe

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in IUCrJ, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Molecular mechanisms of plant NLR activation and signalling.The Plant journal : for cell and molecular biology · 2026
    Review
  5. Article
  6. TheProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Article
  8. Review
  9. Structural basis for TIR domain-mediated innate immune signaling by Toll-like receptor adaptors TRIF and TRAM.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Akansha BhattInstitute for Glycomics, Griffith University, Southport, QLD 4222, Australia.
Biswa P MishraInstitute for Glycomics, Griffith University, Southport, QLD 4222, Australia.ORCID 0000-0001-7069-3138
Weixi GuSchool of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, QLD 4072, Australia.ORCID 0000-0002-1185-3557
Mitchell SorbelloSchool of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, QLD 4072, Australia.
Hongyi XuSchool of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, QLD 4072, Australia.ORCID 0000-0002-8271-3906
Thomas VeInstitute for Glycomics, Griffith University, Southport, QLD 4222, Australia.
Bostjan KobeSchool of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, QLD 4072, Australia.ORCID 0000-0001-9413-9166

Funding

Australian Research Council DP220102832Australian Research Council FL180100109Australian Research Council FT200100572National Health and Medical Research Council 1108859National Health and Medical Research Council 1160570National Health and Medical Research Council 1196590National Health and Medical Research Council 2025931
6 · The paper itself

Abstract

The TIR (Toll/interleukin-1 receptor) domain represents a vital structural element shared by proteins with roles in immunity signalling pathways across phyla (from humans and plants to bacteria). Decades of research have finally led to identifying the key features of the molecular basis of signalling by these domains, including the formation of open-ended (filamentous) assemblies (responsible for the signalling by cooperative assembly formation mechanism, SCAF) and enzymatic activities involving the cleavage of nucleotides. We present a historical perspective of the research that led to this understanding, highlighting the roles that different structural methods played in this process: X-ray crystallography (including serial crystallography), microED (micro-crystal electron diffraction), NMR (nuclear magnetic resonance) spectroscopy and cryo-EM (cryogenic electron microscopy) involving helical reconstruction and single-particle analysis. This perspective emphasizes the complementarity of different structural approaches.

Indexed as

Multiprotein ComplexesReceptors, ImmunologicSignal TransductionCryoelectron MicroscopyCrystallography, X-RayHumansImmunity, InnateMagnetic Resonance SpectroscopyProtein DomainsReceptors, Interleukin-1Multiprotein ComplexesReceptors, ImmunologicReceptors, Interleukin-1helical reconstructioninnate immunitymicro-electron diffractionserial femtosecond crystallographysignalosomesToll/interleukin-1 receptor

Identifiers

PMID39190506
PMCPMC11364022

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.