Evidence map›Paper›PMID 39190491›Full record

ArticleRNA biology2024

FMRP cooperates with miRISC components to repress translation and regulate neurite morphogenesis in

Navneeta Kaul, Sarala J Pradhan, Nathan G Boin, Madeleine M Mason, Julian Rosales, Emily L Starke, Emily C Wilkinson, Erich G Chapman, Scott A Barbee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RNA biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Navneeta KaulDepartment of Biological Sciences, University of Denver, Denver, CO, USA.
Sarala J PradhanDepartment of Biological Sciences, University of Denver, Denver, CO, USA.
Nathan G BoinDepartment of Biological Sciences, University of Denver, Denver, CO, USA.
Madeleine M MasonDepartment of Biological Sciences, University of Denver, Denver, CO, USA.
Julian RosalesDepartment of Chemistry and Biochemistry, University of Denver, Denver, CO, USA.
Emily L StarkeDepartment of Biological Sciences, University of Denver, Denver, CO, USA.
Emily C WilkinsonDepartment of Biological Sciences, University of Denver, Denver, CO, USA.
Erich G ChapmanDepartment of Biological Sciences, University of Denver, Denver, CO, USA.
Scott A BarbeeDepartment of Biological Sciences, University of Denver, Denver, CO, USA.

Funding

Exploring roles for FMR/P-bodies in presynaptic developmentR15MH114019 · NIMH · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI BARBEE, SCOTT A · 2018 to 2018
$434k
NIMH NIH HHS R15 MH114019
6 · The paper itself

Abstract

Fragile X Syndrome (FXS) is the most common inherited form of intellectual disability and is caused by mutations in the gene encoding the Fragile X messenger ribonucleoprotein (FMRP). FMRP is an evolutionarily conserved and neuronally enriched RNA-binding protein (RBP) with functions in RNA editing, RNA transport, and protein translation. Specific target RNAs play critical roles in neurodevelopment, including the regulation of neurite morphogenesis, synaptic plasticity, and cognitive function. The different biological functions of FMRP are modulated by its cooperative interaction with distinct sets of neuronal RNA and protein-binding partners. Here, we focus on interactions between FMRP and components of the microRNA (miRNA) pathway. Using the

Indexed as

Drosophila ProteinsFragile X Messenger Ribonucleoprotein 1MicroRNAsNeuritesProtein BiosynthesisAnimalsDrosophilaDrosophila melanogasterMorphogenesisProtein BindingRNA-Binding ProteinsRNA-Induced Silencing ComplexDrosophila ProteinsFMR1 protein, DrosophilaFragile X Messenger Ribonucleoprotein 1MicroRNAsRNA-Binding ProteinsRNA-Induced Silencing ComplexDrosophilaFMRPFXSmiRNA pathwayRNA-binding proteins

Identifiers

PMID39190491
PMCPMC11352701

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.