ArticleProceedings of the National Academy of Sciences of the United States of America2024
Selective optogenetic inhibition of Gα
Jayde L Lockyer, Andrew Reading, Silvia Vicenzi, Agnieszka Zbela, Saranya Viswanathan, Caroline Delandre, Jake W Newland, John P D McMullen, Owen J Marshall, Robert Gasperini and 2 more
Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
12 authors.
Jayde L LockyerTasmanian School of Medicine, University of Tasmania, Hobart, TAS 7000, Australia.
Andrew ReadingTasmanian School of Medicine, University of Tasmania, Hobart, TAS 7000, Australia.
Silvia VicenziTasmanian School of Medicine, University of Tasmania, Hobart, TAS 7000, Australia.
Agnieszka ZbelaTasmanian School of Medicine, University of Tasmania, Hobart, TAS 7000, Australia.ORCID 0000-0002-7306-1168
Saranya ViswanathanTasmanian School of Medicine, University of Tasmania, Hobart, TAS 7000, Australia.
Caroline DelandreMenzies Institute of Medical Research, University of Tasmania, Hobart, TAS 7000, Australia.ORCID 0000-0002-3367-7427
Jake W NewlandMenzies Institute of Medical Research, University of Tasmania, Hobart, TAS 7000, Australia.ORCID 0009-0002-5305-7775
John P D McMullenMenzies Institute of Medical Research, University of Tasmania, Hobart, TAS 7000, Australia.
Owen J MarshallMenzies Institute of Medical Research, University of Tasmania, Hobart, TAS 7000, Australia.
Robert GasperiniTasmanian School of Medicine, University of Tasmania, Hobart, TAS 7000, Australia.
Lisa FoaSchool of Psychological Sciences, University of Tasmania, Sandy Bay, TAS 7005, Australia.ORCID 0000-0003-4131-8341
John Y LinTasmanian School of Medicine, University of Tasmania, Hobart, TAS 7000, Australia.ORCID 0000-0002-1723-4597
Funding
Optogenetic mapping of synaptic activity and control of intracellular signalingU01NS090590 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KLEINFELD, DAVID, LIN, JOHN YU-LUEN · 2014 to 2016
$1.2M
Department of Education and Training | Australian Research Council (ARC) FT160100056DHAC | National Health and Medical Research Council (NHMRC) APP1128784DHAC | National Health and Medical Research Council (NHMRC) APP1165616DHAC | National Health and Medical Research Council (NHMRC) APP1185220HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) U01NS090590Ian Potter Foundation (IPF) 20190091NINDS NIH HHS U01 NS090590
6 · The paper itself
Abstract
Optogenetic techniques provide genetically targeted, spatially and temporally precise approaches to correlate cellular activities and physiological outcomes. In the nervous system, G protein-coupled receptors (GPCRs) have essential neuromodulatory functions through binding extracellular ligands to induce intracellular signaling cascades. In this work, we develop and validate an optogenetic tool that disrupts Gα
Indexed as
Caenorhabditis elegansGTP-Binding Protein alpha Subunits, Gq-G11OptogeneticsRGS ProteinsSignal TransductionZebrafishAnimalsDrosophilaGanglia, SpinalGTP-Binding Protein alpha Subunits, Gi-GoNeuronsProtein DomainsReceptors, G-Protein-CoupledGTP-Binding Protein alpha Subunits, Gi-GoGTP-Binding Protein alpha Subunits, Gq-G11Receptors, G-Protein-CoupledRGS ProteinsGPCRoptogeneticsRGStrimeric G protein
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Selective optogenetic inhibition of Gα · full record | OpenQuestion