Evidence map›Paper›PMID 39190286›Full record

ArticleJournal of fluorescence2025

Sustainable and Green Fluorescence Method for the Determination of Cloperastine in Human Plasma: Greenness Assessment.

Abobakr A Mohamed, Mahmoud A Omar, Eman Alzahrani, Mohamed A Abdel-Lateef, Islam M Mostafa

Abstract read
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In one paragraph

Article in Journal of fluorescence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Abobakr A MohamedPharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Fayoum University, Fayoum, 63514, Egypt.
Mahmoud A OmarDepartment of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University, Al- Madinah Al-Munawwarah, 41477, Saudi Arabia.
Eman AlzahraniDepartment of Chemistry, College of Science, Taif University, PO Box 11099, Taif, 21944, Saudi Arabia.
Mohamed A Abdel-LateefDepartment of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, 71524, Egypt. mohamed_abdellateef@azhar.edu.eg.
Islam M MostafaAnalytical Chemistry Department, Faculty of Pharmacy, Minia University, Minia, 61511, Egypt. dr_islam@mail.ustc.edu.cn.

Funding

Taif University TU-DSPP-2024-18‎
6 · The paper itself

Abstract

A newly green method for the sensitive quantification of cloperastine, a cough suppressant, in spiked human plasma and its pharmaceutical formulation was designed for the first time. The established method depends on the enhancement of the weak fluorescence of cloperastine using 50 mM sulfuric acid to impair the photoinduced electron transfer produced from the nitrogen atom of piperidine moiety in cloperastine. This full protonation in an acid medium leads to an enhancement in the fluorescence of cloperastine, permitting its linear determination from 0.2 to 5.0 µg/mL with LOD and LOQ of 0.04 and 0.13 µg/mL, respectively. Moreover, the studied drug was estimated in its pharmaceutical market formulations as well as spiked human plasma. Furthermore, the greenness of the described method was evaluated.

Indexed as

Green Chemistry TechnologyPiperidinesFluorescenceHumansSpectrometry, FluorescencePiperidinesCloperastineGreennessHuman plasmaPhotoinduced electron transfer

Identifiers

PMID39190286

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.