Evidence map›Paper›PMID 39190204›Full record

ArticleApoptosis : an international journal on programmed cell death2024

Heme oxygenase-1 binds gasdermin D to inhibit airway epithelium pyroptosis in allergic asthma.

Jiajia Lv, Min Wu, Zhenwei Xia

Abstract readLetter
PubMed Publisher
In one paragraph

Article in Apoptosis : an international journal on programmed cell death, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Programmed Cell Death in Chronic Rhinosinusitis.Clinical and translational allergy · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jiajia LvDepartment of Pediatrics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025, China.
Min WuWenzhou Institute, University of the Chinese Academy of Sciences, Jinlian Road, Longwan District, Wenzhou, 325000, Zhejiang, China. minwoo2022@126.com.
Zhenwei XiaDepartment of Pediatrics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025, China. xzw10484@rjh.com.cn.

Funding

National Natural Science Foundation of China 81900015
6 · The paper itself

Abstract

This study explores how heme oxygenase-1 affects allergic airway inflammation, specifically focusing on airway epithelium pyroptosis. Findings suggest heme oxygenase-1 binds gasdermin D C-terminal to limit release of N-terminal, which affects NLRP3-caspase 1-gasdermin D trimer formation. This enhances comprehension of anti-inflammatory activity of heme oxygenase-1 in allergic disorders.

Indexed as

AsthmaHeme Oxygenase-1Intracellular Signaling Peptides and ProteinsPhosphate-Binding ProteinsPyroptosisAnimalsCaspase 1GasderminsHumansMiceNLR Family, Pyrin Domain-Containing 3 ProteinProtein BindingRespiratory MucosaCaspase 1GasderminsGSDMD protein, humanHeme Oxygenase-1Intracellular Signaling Peptides and ProteinsNLR Family, Pyrin Domain-Containing 3 ProteinPhosphate-Binding Proteins

Identifiers

PMID39190204

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.