Evidence map›Paper›PMID 39190197›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2024

Preclinical evaluation of the novel [

Franziska Zajicek, Jeroen Verhaeghe, Stef De Lombaerde, Annemie Van Eetveldt, Alan Miranda, Ignacio Munoz-Sanjuan, Celia Dominguez, Vinod Khetarpal, Jonathan Bard, Longbin Liu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. In Vivo PET Imaging of [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  2. Preclinical evaluation of [Journal of molecular medicine (Berlin, Germany) · 2025
    Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Franziska ZajicekMolecular Imaging Center Antwerp (MICA), University of Antwerp, Antwerp, Belgium.ORCID 0000-0001-5410-687X
Jeroen VerhaegheMolecular Imaging Center Antwerp (MICA), University of Antwerp, Antwerp, Belgium.ORCID 0000-0002-4493-1902
Stef De LombaerdeMolecular Imaging Center Antwerp (MICA), University of Antwerp, Antwerp, Belgium.ORCID 0000-0002-5307-3575
Annemie Van EetveldtMolecular Imaging Center Antwerp (MICA), University of Antwerp, Antwerp, Belgium.ORCID 0000-0002-6488-5456
Alan MirandaMolecular Imaging Center Antwerp (MICA), University of Antwerp, Antwerp, Belgium.ORCID 0000-0002-5381-015X
Ignacio Munoz-SanjuanCHDI Management, Inc., the company that manages the scientific activities of CHDI Foundation, Inc., Los Angeles, CA, USA.
Celia DominguezCHDI Management, Inc., the company that manages the scientific activities of CHDI Foundation, Inc., Los Angeles, CA, USA.
Vinod KhetarpalCHDI Management, Inc., the company that manages the scientific activities of CHDI Foundation, Inc., Los Angeles, CA, USA.ORCID 0000-0002-2175-5117
Jonathan BardCHDI Management, Inc., the company that manages the scientific activities of CHDI Foundation, Inc., Los Angeles, CA, USA.ORCID 0000-0002-5097-1361
Longbin LiuCHDI Management, Inc., the company that manages the scientific activities of CHDI Foundation, Inc., Los Angeles, CA, USA.ORCID 0000-0003-3995-0196
Steven StaelensMolecular Imaging Center Antwerp (MICA), University of Antwerp, Antwerp, Belgium.ORCID 0000-0003-3376-0519
Daniele BertoglioMolecular Imaging Center Antwerp (MICA), University of Antwerp, Antwerp, Belgium. daniele.bertoglio@uantwerpen.be.ORCID 0000-0003-4205-5432

Funding

CHDI Foundation A-11627Research Foundation Flanders 1229721NUniversiteit Antwerpen FFB210050
6 · The paper itself

Abstract

purposePositron emission tomography (PET) imaging of mutant huntingtin (mHTT) aggregates is a potential tool to monitor disease progression as well as the efficacy of candidate therapeutic interventions for Huntington's disease (HD). To date, the focus has been mainly on the investigation of

methodsAfter characterising [

resultsPlasma and brain radiometabolite profiles indicated a suitable metabolic profile for in vivo imaging of [

conclusionOverall, [

Indexed as

Fluorine RadioisotopesHuntingtin ProteinHuntington DiseasePositron-Emission TomographyProtein AggregatesAnimalsBrainDisease Models, AnimalLigandsMaleMiceMutationRadiopharmaceuticalsFluorine-18Fluorine RadioisotopesHuntingtin ProteinLigandsProtein AggregatesRadiopharmaceuticalsHDmHTT aggregatesMouseProteinopathyzQ175DN

Identifiers

PMID39190197
PMCPMC11599348

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.