Evidence map›Paper›PMID 39190184›Full record

Observational studyClinical research in cardiology : official journal of the German Cardiac Society2025

J-shaped relationship between serum creatinine and mortality in Korean patients with acute heart failure.

Yun-Ho Cho, Jin Joo Park, Hae-Young Lee, Kye Hun Kim, Byung-Su Yoo, Seok-Min Kang, Sang Hong Baek, Eun-Seok Jeon, Jae-Joong Kim, Myeong-Chan Cho and 3 more

Abstract readMulticenter StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in Clinical research in cardiology : official journal of the German Cardiac Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yun-Ho ChoCardiovascular Center, Division of Cardiology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Gumiro 166, Bundang, Seongnam, Gyeonggi-Do, Republic of Korea.
Jin Joo ParkCardiovascular Center, Division of Cardiology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Gumiro 166, Bundang, Seongnam, Gyeonggi-Do, Republic of Korea.
Hae-Young LeeDepartment of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Kye Hun KimHeart Research Center of Chonnam National University, Gwangju, Republic of Korea.
Byung-Su YooYonsei University Wonju College of Medicine, Wonju, Republic of Korea.
Seok-Min KangYonsei University College of Medicine, Seoul, Republic of Korea.
Sang Hong BaekDepartment of Internal Medicine, the Catholic University of Korea, Seoul, Republic of Korea.
Eun-Seok JeonDepartment of Internal Medicine, Sungkyunkwan University College of Medicine, Seoul, Republic of Korea.
Jae-Joong KimDivision of Cardiology, Asan Medical Center, Seoul, Republic of Korea.
Myeong-Chan ChoChungbuk National University College of Medicine, Cheongju, Republic of Korea.
Shung Chull ChaeKyungpook National University College of Medicine, Daegu, Republic of Korea.
Byung-Hee OhMediplex Sejong Hospital, Incheon, Republic of Korea.
Dong-Ju ChoiCardiovascular Center, Division of Cardiology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Gumiro 166, Bundang, Seongnam, Gyeonggi-Do, Republic of Korea. djchoi@snubh.org.ORCID http://orcid.org/0000-0003-0146-2189

Funding

Korea Centers for Disease Control and Prevention 2010-E63003-00Korea Centers for Disease Control and Prevention 2011-E63002-00Korea Centers for Disease Control and Prevention 2012-E63005-00Korea Centers for Disease Control and Prevention 2013-E63003-00Korea Centers for Disease Control and Prevention 2013-E63003-01Korea Centers for Disease Control and Prevention 2013-E63003-02Korea Centers for Disease Control and Prevention 2016-ER6303-00
6 · The paper itself

Abstract

backgroundCachexia and sarcopenia are common among heart failure (HF) patients and are linked to poor outcomes. As serum creatinine levels are influenced by both renal function and muscle mass, our study aimed to investigate the relationship between serum creatinine levels and mortality in acute HF patients.

methodsWe enrolled 5198 consecutive acute HF patients from the Korea Acute Heart Failure (KorAHF) registry, excluding those on renal replacement therapy. Patients were categorized into five groups based on their discharge serum creatinine levels: low (< 0.6 mg/dL), reference (0.6-0.89 mg/dL), upper normal (0.9-1.19 mg/dL), high (1.2-1.49 mg/dL), and very high (≥ 1.5 mg/dL). The primary endpoint was post-discharge all-cause mortality.

resultsThe mean creatinine level was 1.20 ± 0.88 mg/dL. Notably, 335 (6.4%) patients had serum creatinine levels < 0.6 mg/dL. These patients were younger (mean age, 67 years) and more likely to have a low BMI (< 18.5 kg/m

conclusionsAmong acute HF patients, there exists a J-shaped relationship between discharge serum creatinine levels and mortality, highlighting the increased mortality risk in individuals with very low serum creatinine levels.

Indexed as

CreatinineHeart FailureRegistriesAcute DiseaseAgedBiomarkersCause of DeathFemaleFollow-Up StudiesHumansMaleMiddle AgedPrognosisProspective StudiesRepublic of KoreaRisk FactorsBiomarkersCreatinineAcute heart failureBUNCreatinineJ-shaped relationshipMortality

Identifiers

PMID39190184

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.