Evidence map›Paper›PMID 39190120›Full record

ArticleThe protein journal2024

Dual Antimicrobial and Anticancer Activity of Membrane-Active Peptide BP52.

Hai Bui Thi Phuong, Hoa Doan Ngan, Hue Pham Thi, Binh Nguyen Thi Thanh, Tien T Dang, Thao N T Ho, Tung Truong Thanh, Minh Nguyen Hong, Huy Luong Xuan

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Article in The protein journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hai Bui Thi PhuongFaculty of Pharmacy, Phenikaa University, Hanoi, 12116, Vietnam.
Hoa Doan NganFaculty of Medical Technology, Phenikaa University, Hanoi, 12116, Vietnam.
Hue Pham ThiBioresource Research Center, Phenikaa University, Hanoi, 12116, Vietnam.
Binh Nguyen Thi ThanhVNU University of Medicine and Pharmacy, 144 Xuan Thuy, Cau Giay, Hanoi, Vietnam.
Tien T DangInstitute of Applied Materials Science, Vietnam Academy of Science and Technology, 1B TL29, District 12, Ho Chi Minh City, Vietnam.
Thao N T HoVN-UK Institute for Research and Executive Education, The University of Danang, Danang, 550000, Vietnam.
Tung Truong ThanhFaculty of Pharmacy, Phenikaa University, Hanoi, 12116, Vietnam.
Minh Nguyen HongFaculty of Biotechnology, Chemistry and Environmental Engineering, Phenikaa University, Hanoi, 12116, Vietnam.
Huy Luong XuanFaculty of Pharmacy, Phenikaa University, Hanoi, 12116, Vietnam. huy.luongxuan@phenikaa-uni.edu.vn.

Funding

National Foundation for Science and Technology Development 108.05-2021.06
6 · The paper itself

Abstract

The linear undecapeptide BP52 was previously reported to have antibacterial activity against phytopathogenic bacteria species. Due to the structural similarities to naturally occurring cationic helical antimicrobial peptides, it was speculated that this peptide could potentially target microbial pathogens and cancer cells found in mammals. Consequently, this study aims to further investigate the structural and biological properties of this peptide. Our findings indicate that BP52 exhibits strong antimicrobial and anticancer activity while displaying relatively low levels of hemolytic activity. Hence, this study suggests that BP52 could be a potential lead compound for drug discovery against infectious diseases and cancer. Besides, new insights into the relationships between the structure and the multifunctional properties of antimicrobial peptides were also explored.

Indexed as

Antineoplastic AgentsAnti-Bacterial AgentsAntimicrobial Cationic PeptidesAntimicrobial PeptidesCell Line, TumorHemolysisHumansMicrobial Sensitivity TestsAnti-Bacterial AgentsAntimicrobial Cationic PeptidesAntimicrobial PeptidesAntineoplastic AgentsAlternative antibioticsAmphipathic helixAnticancer peptidesAntimicrobial peptidesStructure-activity relationships

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.