Evidence map›Paper›PMID 39190025›Full record

ArticleMicrobiology (Reading, England)2024

Natural products from food sources can alter the spread of antimicrobial resistance plasmids in

Ilyas Alav, Parisa Pordelkhaki, Judith Rodriguez-Navarro, Onalenna Neo, Celia Kessler, Ruth Jesujobalayemi Awodipe, Poppy Cliffe, Nivethanaa Pulavan, Huba L Marton, Simon Gibbons and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology (Reading, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Transfer ofFrontiers in microbiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ilyas AlavInstitute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Parisa PordelkhakiInstitute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Judith Rodriguez-NavarroDepartment of Microbiology, Hospital de la Santa Creu i Sant Pau, Institut d'Investigació Biomèdica Sant Pau (IIB Sant Pau), Sant Quintıí 89, E-08041 Barcelona, Spain.
Onalenna NeoSchool of Dentistry, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Celia KesslerInstitute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Ruth Jesujobalayemi AwodipeWarwick Medical School, University of Warwick, Coventry, UK.
Poppy CliffeInstitute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Nivethanaa PulavanInstitute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Huba L MartonInstitute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Simon GibbonsNatural and Medical Sciences Research Center, University of Nizwa, P.O. Box 33, Birkat Al Mauz, Nizwa 616, Sultanate of Oman.
Michelle M C BucknerInstitute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimicrobial resistance (AMR) poses a significant threat to global public health. Notably, resistance to carbapenem and extended-spectrum β-lactam antibiotics in Gram-negative bacteria is a major impediment to treating infections. Genes responsible for antibiotic resistance are frequently carried on plasmids, which can transfer between bacteria. Therefore, exploring strategies to prevent this transfer and the prevalence of AMR plasmids is timely and pertinent. Here, we show that certain natural product extracts and associated pure compounds can reduce the conjugation of AMR plasmids into new bacterial hosts. Using our established high-throughput fluorescence-based flow cytometry assay, we found that the natural products were more active in reducing transmission of the IncK extended-spectrum β-lactamase-encoding plasmid pCT in

Indexed as

Anti-Bacterial Agentsbeta-LactamasesBiological ProductsEscherichia coliKlebsiella pneumoniaePlasmidsBacterial ProteinsConjugation, GeneticDrug Resistance, BacterialEnterobacteriaceaeFood MicrobiologyGene Transfer, HorizontalMicrobial Sensitivity TestsAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasesBiological Productsantibiotic resistanceanti-plasmidconjugationE. coliK. pneumoniae

Identifiers

PMID39190025
PMCPMC11541548

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.