Evidence map›Paper›PMID 39189891›Full record

ArticleAmerican journal of respiratory cell and molecular biology2024

Studying the Pulmonary Endothelium in Health and Disease: An Official American Thoracic Society Workshop Report.

Rebecca F Hough, Cristina M Alvira, Julie A Bastarache, Serpil C Erzurum, Wolfgang M Kuebler, Eric P Schmidt, Larissa A Shimoda, Steven H Abman, Diego F Alvarez, Patrick Belvitch and 24 more

Abstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. A precision approach to translational research in acute lung injury.American journal of respiratory and critical care medicine · 2026
    Article
  2. Equip your vehicle for the right terrain: Using features of local pathology to guide engineering of targeted drug delivery systems.Journal of controlled release : official journal of the Controlled Release Society · 2026
    Review
  3. Article
  4. Article
  5. From development to regeneration: the endothelial interface in lung injury and repair.American journal of physiology. Lung cellular and molecular physiology · 2025
    Review
  6. Mechanisms of lung crosstalk with end organs: scientific session V-ReSPIRE 2025.American journal of physiology. Lung cellular and molecular physiology · 2025
    Review
  7. Lung endothelial cell heterogeneity in health and pulmonary vascular disease.American journal of physiology. Lung cellular and molecular physiology · 2025
    Review
  8. Development of a preclinical model of ICU-associated sleep fragmentation and effects on pneumonia recovery in mice.American journal of physiology. Lung cellular and molecular physiology · 2025
    Article
  9. Review
  10. The vascular endothelium as decision maker in lung injury.Frontiers in cell and developmental biology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

Cristina M AlviraORCID 0000-0002-6921-0001
Julie A Bastarache
Serpil C Erzurum
Wolfgang M KueblerORCID 0000-0003-4100-2961
Larissa A ShimodaORCID 0000-0001-5987-1378
Patrick Belvitch
Jahar BhattacharyaORCID 0000-0002-5588-6211
Konstantin G BirukovORCID 0000-0002-0303-5394
David N CornfieldORCID 0000-0002-1684-2056
Joe G N Garcia
Elizabeth O HarringtonORCID 0000-0002-3207-5301
Mohammad Naimul Islam
Vladimir V Kalinichenko
Dolly Mehta
Sharon Rounds
Jonas C Schupp
Dhananjay T Tambe
Corey E VentetuoloORCID 0000-0002-4223-4775

Funding

T-type Calcium Channels and von Willebrand Factor ReleaseP01HL066299 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI ALVAREZ, DIEGO F. · 2001 to 2022
$34.6M
Structure-Function Analysis of nmMLCK in EC Barrier ResponsesP01HL126609 · NHLBI · UNIVERSITY OF FLORIDA · PI Joe G. N. Garcia · 2016 to 2026
$24.4M
NITRIC OXIDE PRODUCTION AND REACTIONS IN THE LUNGR01HL060917 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI Serpil C. Erzurum · 1999 to 2026
$6.3M
Transcriptional Regulation of Endothelial Cells after Neonatal Lung InjuryR01HL141174 · NHLBI · UNIVERSITY OF ARIZONA · PI Vladimir Kalinichenko · 2018 to 2026
$4.7M
Novel Involvement of NAMPT and TLR4 in PAH Vascular RemodelingR01HL141387 · NHLBI · UNIVERSITY OF FLORIDA · PI Joe G. N. Garcia, Ayako Makino · 2019 to 2026
$3.8M
Pathobiology of MRSA-induced Endothelial Permeability and Acute Lung InjuryR01HL167518 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI STEVEN M DUDEK · 2023 to 2026
$2.6M
Targeting mechanisms activating ion-channel for preventing acute lung injuryR01HL165263 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DOLLY MEHTA · 2023 to 2026
$2.4M
Targeting Divergent Roles of Caspase 3 to Promote Endothelial Barrier RecoveryR01HL173981 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Mahendra Damarla · 2024 to 2026
$2.2M
Targeting Divergent Roles of Caspase 3 to Promote Endothelial Barrier IntegrityR01HL133413 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI DAMARLA, MAHENDRA · 2016 to 2020
$2.0M
Soluble adenylyl cyclases in lung endothelial tauopathyR01HL167997 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI Troy Stevens · 2023 to 2026
$1.9M
Preclinical Development of a Novel eNAMPT-Neutralizing mAb for Pulmonary HypertensionR42HL164300 · NHLBI · AQUALUNG THERAPEUTICS CORP. · PI GARCIA, JOE G. N. · 2022 to 2024
$1.9M
Lung Endothelial Aß in infectious proteinopathyR01HL148069 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI STEVENS, TROY · 2020 to 2023
$1.5M
NHLBI NIH HHS P01 HL066299NHLBI NIH HHS P01 HL126609NHLBI NIH HHS R01 HL060917NHLBI NIH HHS R01 HL133413NHLBI NIH HHS R01 HL141174NHLBI NIH HHS R01 HL141387NHLBI NIH HHS R01 HL148069NHLBI NIH HHS R01 HL165263NHLBI NIH HHS R01 HL167518NHLBI NIH HHS R01 HL167997NHLBI NIH HHS R01 HL173981NHLBI NIH HHS R42 HL164300
6 · The paper itself

Abstract

Lung endothelium resides at the interface between the circulation and the underlying tissue, where it senses biochemical and mechanical properties of both the blood as it flows through the vascular circuit and the vessel wall. The endothelium performs the bidirectional signaling between the blood and tissue compartments that is necessary to maintain homeostasis while physically separating both, facilitating a tightly regulated exchange of water, solutes, cells, and signals. Disruption in endothelial function contributes to vascular disease, which can manifest in discrete vascular locations along the artery-to-capillary-to-vein axis. Although our understanding of mechanisms that contribute to endothelial cell injury and repair in acute and chronic vascular disease have advanced, pathophysiological mechanisms that underlie site-specific vascular disease remain incompletely understood. In an effort to improve the translatability of mechanistic studies of the endothelium, the American Thoracic Society convened a workshop to optimize rigor, reproducibility, and translation of discovery to advance our understanding of endothelial cell function in health and disease.

Indexed as

Endothelium, VascularLungAnimalsEndothelial CellsHumansLung DiseasesSocieties, MedicalUnited Statesand translationbarrier integrityendotheliumgenetic manipulationphenotype specificationreproducibilityrigor

Identifiers

PMID39189891
PMCPMC11450313

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.