Evidence map›Paper›PMID 39189882›Full record

ArticleEuropean journal of heart failure2025

Association of ventricular-arterial coupling with biomarkers involved in heart failure pathophysiology - the STANISLAS cohort.

Hannes Holm, Martin Magnusson, Amra Jujić, Jérémy Lagrange, Erwan Bozec, Zohra Lamiral, Emmanuel Bresso, Olivier Huttin, Guillaume Baudry, Luca Monzo and 3 more

Abstract read
In one paragraph

Article in European journal of heart failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Comparative prognostic value of non-invasive ventricular-arterial coupling metrics in the general population.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Left ventricular-arterial coupling parameters predict incident cardiovascular events and mortality in UK Biobank.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Hannes HolmDepartment of Clinical Sciences, Lund University, Malmö, Sweden.
Martin MagnussonDepartment of Clinical Sciences, Lund University, Malmö, Sweden.
Amra JujićDepartment of Clinical Sciences, Lund University, Malmö, Sweden.
Jérémy LagrangeUniversité de Lorraine, Inserm, Centre d'Investigations Cliniques-1433, and Inserm, CHRU Nancy, F-CRIN INI-CRCT, Nancy, France.
Erwan BozecUniversité de Lorraine, Inserm, Centre d'Investigations Cliniques-1433, and Inserm, CHRU Nancy, F-CRIN INI-CRCT, Nancy, France.
Zohra LamiralUniversité de Lorraine, Inserm, Centre d'Investigations Cliniques-1433, and Inserm, CHRU Nancy, F-CRIN INI-CRCT, Nancy, France.
Emmanuel BressoUniversité de Lorraine, Inserm, Centre d'Investigations Cliniques-1433, and Inserm, CHRU Nancy, F-CRIN INI-CRCT, Nancy, France.
Olivier HuttinUniversité de Lorraine, Inserm, Centre d'Investigations Cliniques-1433, and Inserm, CHRU Nancy, F-CRIN INI-CRCT, Nancy, France.
Guillaume BaudryUniversité de Lorraine, Inserm, Centre d'Investigations Cliniques-1433, and Inserm, CHRU Nancy, F-CRIN INI-CRCT, Nancy, France.
Luca MonzoUniversité de Lorraine, Inserm, Centre d'Investigations Cliniques-1433, and Inserm, CHRU Nancy, F-CRIN INI-CRCT, Nancy, France.
Patrick RossignolUniversité de Lorraine, Inserm, Centre d'Investigations Cliniques-1433, and Inserm, CHRU Nancy, F-CRIN INI-CRCT, Nancy, France.
Faiez ZannadUniversité de Lorraine, Inserm, Centre d'Investigations Cliniques-1433, and Inserm, CHRU Nancy, F-CRIN INI-CRCT, Nancy, France.
Nicolas GirerdUniversité de Lorraine, Inserm, Centre d'Investigations Cliniques-1433, and Inserm, CHRU Nancy, F-CRIN INI-CRCT, Nancy, France.

Funding

Crafoord FoundationFrench National Research Agency Fighting Heart Failure ANR-15-RHU-0004Knut and Alice Wallenberg Foundation and the Marianne and Marcus Wallenberg FoundationP.R. are supported by public grants overseen by the European CommissionSkåne University HospitalSwedish Heart and Lung FoundationSwedish Medical Research CouncilWallenberg Centre for Molecular Medicine at Lund University. N.G
6 · The paper itself

Abstract

aimsImpaired left ventricular-arterial coupling (VAC) has been shown to correlate with worse prognosis in cardiac diseases and heart failure (HF). The extent of the relationship between VAC and circulating biomarkers associated with HF has been scarcely documented. We aimed to explore associations of VAC with proteins involved in HF pathophysiology within a large population-based cohort of middle-aged individuals. METHODS AND

resultsIn the forth visit of the STANISLAS family cohort, involving 1309 participants (mean age 48 ± 14 years; 48% male) from parent and children generations, we analysed the association of 32 HF-related proteins with non-invasively assessed VAC using pulse wave velocity (PWV)/global longitudinal strain (GLS) and arterial elastance (E

conclusionElevated MMP-2 and NT-proBNP levels correlate with better VAC (lower PWV/GLS), possibly indicating a compensatory cardiovascular response to regulate left ventricular pressure amidst cardiac remodelling and overload.

Indexed as

Heart FailureHeart VentriclesVascular StiffnessVentricular Function, LeftAdrenomedullinAdultBiomarkersCohort StudiesFemaleHumansMaleMiddle AgedNatriuretic Peptide, BrainPeptide FragmentsPrognosisPulse Wave AnalysisAdrenomedullinBiomarkersNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)CardiovascularEchocardiographyHypertensionVentricular–arterial coupling

Identifiers

PMID39189882
PMCPMC12103963

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.