Evidence map›Paper›PMID 39189851›Full record

ArticleAmerican journal of respiratory and critical care medicine2025

Toll-like Receptor 9 Inhibition Mitigates Fibroproliferative Responses in Translational Models of Pulmonary Fibrosis.

Glenda Trujillo, Alicia Regueiro-Ren, Chunjian Liu, Buqu Hu, Ying Sun, Farida Ahangari, Vitoria Fiorini, Genta Ishikawa, Karam Al Jumaily, Johad Khoury and 13 more

Abstract read
In one paragraph

Article in American journal of respiratory and critical care medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Cell-Free DNA-Based Theranostics for Inflammatory Disorders.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors.

Glenda TrujilloCardiovascular & Fibrotic Diseases Drug Discovery, Bristol Myers Squibb, New York, New York; and.
Alicia Regueiro-RenCardiovascular & Fibrotic Diseases Drug Discovery, Bristol Myers Squibb, New York, New York; and.
Chunjian LiuCardiovascular & Fibrotic Diseases Drug Discovery, Bristol Myers Squibb, New York, New York; and.
Buqu HuSection of Pulmonary, Critical Care, and Sleep Medicine and.
Ying SunSection of Pulmonary, Critical Care, and Sleep Medicine and.
Farida AhangariSection of Pulmonary, Critical Care, and Sleep Medicine and.ORCID 0000-0002-4144-9395
Vitoria FioriniSection of Pulmonary, Critical Care, and Sleep Medicine and.
Genta IshikawaSection of Pulmonary, Critical Care, and Sleep Medicine and.
Karam Al JumailySection of Pulmonary, Critical Care, and Sleep Medicine and.
Johad KhourySection of Pulmonary, Critical Care, and Sleep Medicine and.ORCID 0000-0001-8048-1542
John McGovernSection of Pulmonary, Critical Care, and Sleep Medicine and.
Chris J LeeSection of Pulmonary, Critical Care, and Sleep Medicine and.
Xue Yan PengSection of Pulmonary, Critical Care, and Sleep Medicine and.
Taylor PivarnikSection of Pulmonary, Critical Care, and Sleep Medicine and.
Huanxing SunSection of Pulmonary, Critical Care, and Sleep Medicine and.ORCID 0000-0003-2397-4652
Anjali WaliaSection of Pulmonary, Critical Care, and Sleep Medicine and.
Samuel WooSection of Pulmonary, Critical Care, and Sleep Medicine and.
Sheeline YuSection of Pulmonary, Critical Care, and Sleep Medicine and.
Danielle E Antin-OzerkisSection of Pulmonary, Critical Care, and Sleep Medicine and.
Maor SaulerSection of Pulmonary, Critical Care, and Sleep Medicine and.
Naftali KaminskiSection of Pulmonary, Critical Care, and Sleep Medicine and.ORCID 0000-0001-5917-4601
Erica L HerzogSection of Pulmonary, Critical Care, and Sleep Medicine and.
Changwan RyuSection of Pulmonary, Critical Care, and Sleep Medicine and.ORCID 0000-0001-6211-4327

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
TrainingU54HG008540 · NHGRI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BAHAR, IVET, BERG, JEREMY M · 2014 to 2018
$12.8M
Genomic Analysis of Tissue and Cellular Heterogeneity in IPFR01HL127349 · NHLBI · YALE UNIVERSITY · PI BENOS, PANAGIOTIS V, KAMINSKI, NAFTALI · 2015 to 2025
$5.9M
Alveolar DevMAPU01HL122626 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AMBALAVANAN, NAMASIVAYAM, HAGOOD, JAMES S. · 2014 to 2018
$3.7M
Noradrenergic mechanisms of IPFR01HL163984 · NHLBI · YALE UNIVERSITY · PI Erica L Herzog · 2022 to 2026
$3.7M
Normal Aging Lung Cell Atlas (NALCA)U01HL145567 · NHLBI · YALE UNIVERSITY · PI KAMINSKI, NAFTALI · 2019 to 2022
$2.8M
Macrophage driven, profibrotic adrenergic nerve remodeling in SSc-ILDR01HL152677 · NHLBI · YALE UNIVERSITY · PI HERZOG, ERICA L · 2020 to 2023
$2.4M
Use of the Src Family Kinase Inhibitor Saracatinib in the Treatment of Pulmonary FibrosisUG3TR002445 · NCATS · NATIONAL JEWISH HEALTH · PI DOWNEY, GREGORY PAUL, DUDLEY, JOEL THOMAS · 2018 to 2018
$854k
Mitochondrial DNA and TLR9 in Pulmonary FibrosisK08HL151970 · NHLBI · YALE UNIVERSITY · PI RYU, CHANGWAN · 2020 to 2024
$840k
Boehringer-IngelheimNCATS NIH HHS UG3 TR002445NCATS NIH HHS UL1 TR001863NHGRI NIH HHS U54 HG008540NHLBI NIH HHSNHLBI NIH HHS K08 HL151970NHLBI NIH HHS K08HL151970-01NHLBI NIH HHS R01 HL127349NHLBI NIH HHS R01HL127349NHLBI NIH HHS R01 HL152677NHLBI NIH HHS R01 HL163984NHLBI NIH HHS U01 HL122626NHLBI NIH HHS U01HL122626NHLBI NIH HHS U01 HL145567NHLBI NIH HHS U01HL145567NHLBI NIH HHS U54HG008540NHLBI NIH HHS UG3TR002445Pulmonary Fibrosis FoundationYale ILD Center of Excellence
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Idiopathic Pulmonary FibrosisToll-Like Receptor 9AgedAnimalsCell ProliferationDisease Models, AnimalDNA, MitochondrialFemaleFibroblastsHumansMaleMiceMiddle AgedDNA, MitochondrialTLR9 protein, humanToll-Like Receptor 9idiopathic pulmonary fibrosismitochondrial DNATLR9

Identifiers

PMID39189851
PMCPMC11755360

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.