Observational studyClinical infectious diseases : an official publication of the Infectious Diseases Society of America2025
Prosthetic Joint Infections due to Candida Species: A Multicenter International Study.
Observational study in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Optimized use and performance of culture for periprosthetic joint infection diagnosis: a comprehensive literature review.Clinical microbiology reviews · 2025Pooled it
- Brazilian guidelines for the diagnosis and treatment of candidemia and invasive candidiasis in adults and children.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesGuideline
- Emerging antifungal strategies against Candida albicans using metal-organic frameworks and novel therapeutics: Opportunities and challenges.Journal of food and drug analysis · 2026Review
- How long should we keep clinical isolates involved in bone and joint infections in microbiology laboratories?European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Review
- Daily Low-Dose Intra-Articular Povidone-Iodine Salvage of Refractory Fungal Total Knee Arthroplasty Infection: A Case Report.JBJS case connector · 2026Article
- Periprosthetic Joint Infection: Biofilm Pathogenesis, Immune Dysregulation, and Emerging Prosthetic Interface Strategies.Biology · 2026Review
- Non-intravenous Amphotericin B: A Review of Localized Administration Routes.Infectious diseases and therapy · 2026Review
- Ultrasound-triggered microbubble delivery of voriconazole for enhanced reduction of Candida albicans biofilms in vitro.Bone & joint research · 2026Article
- Geographical Differences in the Epidemiology and Treatment of Candida Prosthetic Joint Infections.Open forum infectious diseases · 2026Article
- Two-stage revision combined with anti-infective therapy for mixed fungal and bacterial knee periprosthetic joint infection: a case report and literature review.BMC musculoskeletal disorders · 2026Review
- Candida albicans Periprosthetic Hip Infection Complicated by Recurrent Dislocations Following Revision Total Hip Arthroplasty: A Case Report.Journal of orthopaedic case reports · 2026Article
- Osteomyelitis in peri-implant bone of hip prosthetic joint infection: prevalence and clinical impact.Journal of bone and joint infection · 2026Article
- Prosthetic knee joint infection caused by Aspergillus penicillioides: a case report.BMC infectious diseases · 2025Article
- What is the most advantageous lavage solution to use for fungal prosthetic joint infections.Journal of clinical orthopaedics and trauma · 2025Article
- Outcome Predictors ofOpen forum infectious diseases · 2025Article
- Rare case of prosthetic and non-prosthetic Candida arthritis of bilateral knee joints byIDCases · 2025Article
- Musculoskeletal Manifestations of Disseminated Fungal Infections.JB & JS open accessReview
Corrections and comments
- Erratum issued
Authors and funding
47 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundProsthetic joint infection (PJI) caused by Candida spp is a severe complication of arthroplasty. We investigated the outcomes of Candida PJI.
methodsThis was a retrospective observational multinational study including patients diagnosed with Candida-related PJI between 2010 and 2021. Treatment outcome was assessed at 2-year follow-up.
resultsA total of 269 patients were analyzed. Median age was 73.0 (interquartile range [IQR], 64.0-79.0) years; 46.5% of patients were male and 10.8% were immunosuppressed. Main infection sites were hip (53.0%) and knee (43.1%), and 33.8% patients had fistulas. Surgical procedures included debridement, antibiotics, and implant retention (DAIR) (35.7%), 1-stage exchange (28.3%), and 2-stage exchange (29.0%). Candida spp identified were Candida albicans (55.8%), Candida parapsilosis (29.4%), Candida glabrata (7.8%), and Candida tropicalis (5.6%). Coinfection with bacteria was found in 51.3% of cases. The primary antifungal agents prescribed were azoles (75.8%) and echinocandins (30.9%), administered for a median of 92.0 (IQR, 54.5-181.3) days. Cure was observed in 156 of 269 (58.0%) cases. Treatment failure was associated with age >70 years (OR, 1.811 [95% confidence interval {CI}: 1.079-3.072]), and the use of DAIR (OR, 1.946 [95% CI: 1.157-3.285]). Candida parapsilosis infection was associated with better outcome (OR, 0.546 [95% CI: .305-.958]). Cure rates were significantly different between DAIR versus 1-stage exchange (46.9% vs 67.1%, P = .008) and DAIR versus 2-stage exchange (46.9% vs 69.2%, P = .003), but there was no difference comparing 1- to 2-stage exchanges (P = .777).
conclusionsCandida PJI prognosis seems poor, with high rate of failure, which does not appear to be linked to immunosuppression, use of azoles, or treatment duration.
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