Evidence map›Paper›PMID 39189775›Full record

ArticlemSphere2024

Identification and characterization of archaeal-type FAD synthase as a novel tractable drug target from the parasitic protozoa

Dewi Wulansari, Ghulam Jeelani, Euki Yazaki, Tomoyoshi Nozaki

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSphere, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Dewi Wulansari *Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.ORCID 0000-0003-1904-7741
Ghulam Jeelani *Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.ORCID 0000-0003-0816-9831
Euki YazakiResearch Center for Advanced Analysis, National Agriculture and Food Research Organization, Ibaraki, Japan.
Tomoyoshi NozakiDepartment of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.ORCID 0000-0003-1354-5133

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Flavin adenine dinucleotide (FAD) is an essential cofactor for numerous flavoenzymes present in all living organisms. The biosynthesis of FAD from riboflavin involves two sequential reactions catalyzed by riboflavin kinase and flavin adenine dinucleotide synthase (FADS).

Indexed as

ArchaeaEntamoeba histolyticaFlavin-Adenine DinucleotidePhylogenyAntiprotozoal AgentsHumansKineticsNucleotidyltransferasesProtozoan ProteinsAntiprotozoal AgentsFlavin-Adenine DinucleotideFMN adenylyltransferaseNucleotidyltransferasesProtozoan Proteinscofactordrug targetEntamoeba histolyticaFAD synthaseflavin adenine dinucleotidegene silencingprotozoanriboflavin kinase

Identifiers

PMID39189775
PMCPMC11423594

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.