Evidence map›Paper›PMID 39189642›Full record

ArticleGut microbes

Bacterial amyloid curli activates the host unfolded protein response via IRE1α in the presence of HLA-B27.

Kaitlyn Grando, Shingo Bessho, Kayla Harrell, Kathrine Kyrylchuk, Alejandro M Pantoja, Sophia Olubajo, Francisco J Albicoro, Andres Klein-Szanto, Çagla Tükel

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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  3. Review
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kaitlyn GrandoCenter for Microbiology and Immunology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
Shingo BesshoCenter for Microbiology and Immunology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
Kayla HarrellCenter for Microbiology and Immunology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
Kathrine KyrylchukCenter for Microbiology and Immunology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
Alejandro M PantojaCenter for Microbiology and Immunology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
Sophia OlubajoCenter for Microbiology and Immunology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
Francisco J AlbicoroCenter for Microbiology and Immunology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
Andres Klein-SzantoHistopathology Facility, Fox Chase Cancer Center, Philadelphia, PA, USA.
Çagla TükelCenter for Microbiology and Immunology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.ORCID 0000-0001-7073-0226

Funding

WORD PROCESSING CENTER--COREP30CA006927 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI Eric Andrew Ross · 1985 to 2026
$138.8M
Role of ZBP1 in pathogenesis of Salmonella biofilmsR01AI171568 · NIAID · RESEARCH INST OF FOX CHASE CAN CTR · PI SIDDHARTH BALACHANDRAN, Cagla Tukel · 2023 to 2026
$3.4M
The role of bacterial amyloid curli in Alzheimer's DiseaseR01AI153325 · NIAID · TEMPLE UNIV OF THE COMMONWEALTH · PI TUKEL, CAGLA · 2020 to 2024
$2.4M
Pathogenicity of amyloid containing biofilmsR21AI148770 · NIAID · TEMPLE UNIV OF THE COMMONWEALTH · PI TUKEL, CAGLA · 2020 to 2021
$436k
Immune recognition mechanisms of bacterial biofilms in the gutR21AI151893 · NIAID · TEMPLE UNIV OF THE COMMONWEALTH · PI TUKEL, CAGLA · 2020 to 2021
$436k
NCI NIH HHS P30 CA006927NIAID NIH HHS R01 AI153325NIAID NIH HHS R01 AI171568NIAID NIH HHS R21 AI148770NIAID NIH HHS R21 AI151893
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Bacterial ProteinsEndoplasmic Reticulum Chaperone BiPEndoribonucleasesHLA-B27 AntigenMacrophagesProtein Serine-Threonine KinasesSalmonella typhimuriumUnfolded Protein ResponseAnimalsBiofilmsHumansInterleukin-6MiceMice, Inbred C57BLMice, TransgenicSalmonella InfectionsBacterial ProteinsCrl protein, BacteriaEndoplasmic Reticulum Chaperone BiPEndoribonucleasesErn1 protein, mouseHLA-B27 AntigenHSPA5 protein, humanHspa5 protein, mouseInterleukin-6Protein Serine-Threonine KinasesautoimmunitycurliHLA-B27reactive arthritisSalmonellaunfolded protein response

Identifiers

PMID39189642
PMCPMC11352795

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.