Evidence map›Paper›PMID 39189428›Full record

ArticleJournal of cachexia, sarcopenia and muscle2024

Hydrogen sulfide inhibits skeletal muscle ageing by up-regulating autophagy through promoting deubiquitination of adenosine 5'-monophosphate (AMP)-activated protein kinase α1 via ubiquitin specific peptidase 5.

Jia-He Yang, Jun Gao, Ya-Qi E, Li-Jie Jiao, Ren Wu, Qiu-Yi Yan, Zi-Yi Wei, Guo-Liang Yan, Jin-Long Liang, Hong-Zhu Li

Abstract read
In one paragraph

Article in Journal of cachexia, sarcopenia and muscle, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
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  3. Review
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  5. Article
  6. Article
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  9. CSE/HInternational journal of molecular sciences · 2025
    Review
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jia-He YangInstitute of Cardiovascular Diseases, Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China.
Jun GaoDepartment of Emergency Medicine, Xiangan Hospital of Xiamen University, Xiamen, Fujian, China.
Ya-Qi EInstitute of Cardiovascular Diseases, Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China.
Li-Jie JiaoInstitute of Cardiovascular Diseases, Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China.
Ren WuInstitute of Cardiovascular Diseases, Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China.
Qiu-Yi YanInstitute of Cardiovascular Diseases, Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China.
Zi-Yi WeiInstitute of Cardiovascular Diseases, Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China.
Guo-Liang YanInstitute of Cardiovascular Diseases, Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China.
Jin-Long LiangDepartment of General Surgery, Xiamen Fifth Hospital, Xiamen, Fujian, China.
Hong-Zhu LiInstitute of Cardiovascular Diseases, Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China.

Funding

Fujian Provincial Science and Technology Guidance Program 2022D033National Natural Science Foundation of China 81770486Research Initiation Fund (RIF), School of Medicine, Xiamen UniversityXiamen Health Care Guidance Program 3502Z20224ZD1281
6 · The paper itself

Abstract

backgroundHydrogen sulfide (H

methodsMice were administered 150 mg/kg/day of D-galactose (D-gal), and C2C12 myotubes were cultured in 20 g/L D-gal to induce ageing. Sodium hydrosulfide (NaHS) was employed as an exogenous donor in the treatment group. The intracellular concentration of H

resultsNaHS was found to effectively restore the H

conclusionsH

Indexed as

AMP-Activated Protein KinasesAutophagyHydrogen SulfideMuscle, SkeletalAgingAnimalsMaleMiceMice, Inbred C57BLUbiquitinationUbiquitin-Specific ProteasesAMP-Activated Protein KinasesHydrogen SulfidePrkaa1 protein, mouseUbiquitin-Specific ProteasesUsp5 protein, mouseageingautophagydeubiquitinationhydrogen sulfideskeletal muscle

Identifiers

PMID39189428
PMCPMC11446701

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.