Evidence map›Paper›PMID 39189377›Full record

ArticleBiochemistry2024

Conformational and Structural Characterization of Knotted Proteins.

Kevin Jeanne Dit Fouque, Juan Camilo Molano-Arevalo, Fenfei Leng, Francisco Fernandez-Lima

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kevin Jeanne Dit FouqueDepartment of Chemistry and Biochemistry and Biomolecular Sciences Institute, Florida International University, Miami, Florida, 33199, United States.
Juan Camilo Molano-ArevaloDepartment of Chemistry and Biochemistry and Biomolecular Sciences Institute, Florida International University, Miami, Florida, 33199, United States.
Fenfei LengDepartment of Chemistry and Biochemistry and Biomolecular Sciences Institute, Florida International University, Miami, Florida, 33199, United States.ORCID 0000-0002-9024-1216
Francisco Fernandez-LimaDepartment of Chemistry and Biochemistry and Biomolecular Sciences Institute, Florida International University, Miami, Florida, 33199, United States.ORCID 0000-0002-1283-4390

Funding

Development of Multidimensional, Linear and Differential Ion Mobility MS Separations for Middle-Down ProteoformsR01GM134247 · NIGMS · FLORIDA INTERNATIONAL UNIVERSITY · PI FERNANDEZ-LIMA, FRANCISCO · 2019 to 2022
$1.7M
Development of biological structural tools for the study of protein-DNA complexesR35GM153450 · NIGMS · FLORIDA INTERNATIONAL UNIVERSITY · PI Francisco Fernandez-Lima · 2024 to 2026
$1.2M
Targeting transcription-coupled DNA supercoiling for discovering antibiotics against bacterial DNA gyraseR21AI125973 · NIAID · FLORIDA INTERNATIONAL UNIVERSITY · PI LENG, FENFEI · 2017 to 2018
$478k
Novel gyrase inhibitors targeting Mycobacterium tuberculosisR21AI178134 · NIAID · FLORIDA INTERNATIONAL UNIVERSITY · PI LENG, FENFEI, NEFZI, ADEL · 2023 to 2024
$422k
NIAID NIH HHS R21 AI125973NIAID NIH HHS R21 AI178134NIGMS NIH HHS R01 GM134247NIGMS NIH HHS R35 GM153450
6 · The paper itself

Abstract

Knotted proteins are fascinating natural biomolecules whose backbones entangle themselves in a knot. Their particular knotted configurations provide them with a wide range of topological features. However, their folding/unfolding mechanisms, stability, and function are poorly understood. In the present work, native trapped ion mobility spectrometry-mass spectrometry (TIMS-MS) was used for characterizing structural features of two model knotted proteins: a Gordian 5

Indexed as

Protein ConformationUbiquitin ThiolesteraseHumansIon Mobility SpectrometryModels, MolecularProtein FoldingProtein UnfoldingUbiquitin Thiolesterase

Identifiers

PMID39189377
PMCPMC11790308

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.