Evidence map›Paper›PMID 39189328›Full record

ArticleBiomacromolecules2024

Injectable Dendrimer Hydrogel Delivers Melphalan in Both Conjugated and Free Forms for Retinoblastoma.

Remy C Cooper, Juan Wang, Hu Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomacromolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Remy C CooperDepartment of Biomedical Engineering, Virginia Commonwealth University, Richmond, Virginia 23284, United States.
Juan WangCollege of Biomedical Engineering, Sichuan University, Chengdu, Sichuan 610065, China.ORCID 0000-0003-1992-0539
Hu YangLinda and Bipin Doshi Department of Chemical and Biochemical Engineering, Missouri University of Science and Technology, Rolla, Missouri 65409, United States.ORCID 0000-0003-3030-004X

Funding

Back of the eye drug delivery: Novel contact lenses, pathways, and in-silico modelingR01EY034477 · NEI · COLORADO SCHOOL OF MINES · PI ANUJ CHAUHAN, UDAY B KOMPELLA · 2023 to 2026
$1.9M
Hybrid Nanoparticles for GlaucomaR01EY024072 · NEI · VIRGINIA COMMONWEALTH UNIVERSITY · PI KOMPELLA, UDAY B, YANG, HU · 2014 to 2016
$1.3M
NEI NIH HHS R01 EY024072
6 · The paper itself

Abstract

We report the successful synthesis of an injectable dendrimer hydrogel (DH) carrying melphalan, a clinical drug for retinoblastoma treatment, in both conjugated and free forms. Polyamidoamine (PAMAM) dendrimer generation 5 (G5) is surface-modified with an acid-sensitive acetal-dibenzocyclooctyne linker and then undergoes azide-alkyne cycloaddition with melphalan-PEG-N

Indexed as

DendrimersHydrogelsMelphalanRetinoblastomaAnimalsAntineoplastic Agents, AlkylatingCell Line, TumorHumansMiceRetinal NeoplasmsAntineoplastic Agents, AlkylatingDendrimersHydrogelsMelphalanPAMAM Starburst

Identifiers

PMID39189328
PMCPMC11443594

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.