Evidence map›Paper›PMID 39189087›Full record

ArticleInfluenza and other respiratory viruses2024

Comparison of the Effectiveness of Baloxavir and Oseltamivir in Outpatients With Influenza B.

Takahiro Takazono, Genta Ito, Naoki Hosogaya, Naoki Iwanaga, Takuji Komeda, Masayuki Kobayashi, Yoshitake Kitanishi, Eriko Ogura, Hiroshi Mukae

Abstract readComparative Study
In one paragraph

Article in Influenza and other respiratory viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Observational
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Takahiro TakazonoDepartment of Respiratory Medicine, Nagasaki University Hospital, Nagasaki, Japan.ORCID 0000-0002-0696-5386
Genta ItoData Science Department, Shionogi & Co., Ltd., Osaka, Japan.ORCID 0000-0002-5821-4242
Naoki HosogayaClinical Research Center, Nagasaki University Hospital, Nagasaki, Japan.
Naoki IwanagaDepartment of Respiratory Medicine, Nagasaki University Hospital, Nagasaki, Japan.
Takuji KomedaData Science Department, Shionogi & Co., Ltd., Osaka, Japan.
Masayuki KobayashiData Science Department, Shionogi & Co., Ltd., Osaka, Japan.
Yoshitake KitanishiData Science Department, Shionogi & Co., Ltd., Osaka, Japan.
Eriko OguraGlobal Development Division, Shionogi & Co., Ltd., Tokyo, Japan.
Hiroshi MukaeDepartment of Respiratory Medicine, Nagasaki University Hospital, Nagasaki, Japan.

Funding

Shionogi & Co., Ltd.
6 · The paper itself

Abstract

This retrospective cohort study analyzed data from a Japanese health insurance database to assess the effectiveness of baloxavir (n = 4822) for preventing severe events compared with oseltamivir (n = 10,523) in patients with influenza B. The primary endpoint was hospitalization incidence (Days 2-14). The secondary endpoints included intravenous antibacterial drug use, pneumonia hospitalization, heart failure hospitalization, inhalational oxygen requirement, and use of other anti-influenza drugs. The hospitalization incidence was significantly lower with baloxavir (0.15% vs. 0.37%; risk ratio: 2.48, 95% confidence interval: 1.13-5.43). Pneumonia and additional anti-influenza therapy were also less frequent with baloxavir, thus supporting its use. Trial Registration: UMIN Clinical Trials Registry Study ID: UMIN000051382.

Indexed as

Antiviral AgentsDibenzothiepinsInfluenza B virusInfluenza, HumanMorpholinesOseltamivirOutpatientsPyridonesTriazinesAdolescentAdultAgedAged, 80 and overChildChild, PreschoolFemaleAntiviral AgentsbaloxavirDibenzothiepinsMorpholinesOseltamivirPyridinesPyridonesTriazinesbaloxavirdatabasehospitalizationinfluenzaJapaneseoseltamivir

Identifiers

PMID39189087
PMCPMC11347862

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.