Evidence map›Paper›PMID 39188987›Full record

ArticleNature cardiovascular research2023

Propionyl-CoA metabolism links chromatin acylation to cardiac transcription.

Christina Demetriadou, Andrew A Gibb, John W Elrod, Nathaniel W Snyder

Abstract readNews
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature cardiovascular research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Christina DemetriadouDepartment of Cancer Biology, University of Pennsylvania, Philadelphia, PA, USA.
Andrew A GibbAging and Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
John W ElrodAging and Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.ORCID 0000-0003-3925-2224
Nathaniel W SnyderAging and Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.ORCID 0000-0001-5643-8747

Funding

Targeting Pathways Involved in Cardiac Injury for Novel Repair StrategiesP01HL147841 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI KOCH, WALTER J. · 2020 to 2024
$11.4M
Mitochondria and metabolism in neurodegenerationRF1NS121379 · NINDS · TEMPLE UNIV OF THE COMMONWEALTH · PI ELROD, JOHN WILLIAM · 2021 to 2021
$2.3M
Mitochondria and metabolism in neurodegenerationR01NS121379 · NINDS · TEMPLE UNIV OF THE COMMONWEALTH · PI ELROD, JOHN WILLIAM · 2024 to 2025
$1.5M
American Heart Association-American Stroke Association 937591NHLBI NIH HHS P01 HL147841NINDS NIH HHS R01 NS121379NINDS NIH HHS RF1 NS121379
6 · The paper itself

Abstract

The molecular mechanisms that link propionyl-CoA metabolism and epigenetic regulation of gene expression are unclear, as are the implications for heart function. Now, new insights into the modulation of chromatin acylation and transcription by aberrant oxidation of propionyl-CoA are revealed in the dysfunctional hearts of mice with propionic acidemia.

Identifiers

PMID39188987
PMCPMC11346590

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.