Evidence map›Paper›PMID 39188887›Full record

ArticleIJID regions2024

Assessing the burden of disease of gram-negative bloodstream infections in a Brazilian hospital: A retrospective cohort study from 2015 to 2019.

Kehvyn Cedeño, Marcio de Oliveira Silva, Ana Verena Mendes, Adriele Conceição de Castro, Matheus Sales Barbosa, Maria Goreth Barberino, Mitermayer Galvão Dos Reis, Ianick Souto Martins, Joice Neves Reis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in IJID regions, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kehvyn CedeñoGlobal Health Disparities Research Training Program, Icahn School of Medicine at Mount Sinai, New York, USA.
Marcio de Oliveira SilvaProgram of Biotechnology in Health and Investigative Medicine, Instituto Gonçalo Moniz/FIOCRUZ, Salvador, Brazil.
Ana Verena MendesSão Rafael Hospital, Salvador, Brazil.
Adriele Conceição de CastroLaboratory of Research on Clinical Microbiology (LPMC), School of Pharmacy, Federal University of Bahia, Salvador, Brazil.
Matheus Sales BarbosaLaboratory of Research on Clinical Microbiology (LPMC), School of Pharmacy, Federal University of Bahia, Salvador, Brazil.
Maria Goreth BarberinoSão Rafael Hospital, Salvador, Brazil.
Mitermayer Galvão Dos ReisFaculdade de Medicina, Universidade Federal da Bahia, Salvador, Brazil.
Ianick Souto MartinsFaculty of Medicine, Fluminense Federal University Downtown, Rio de Janeiro, Brazil.
Joice Neves ReisProgram of Biotechnology in Health and Investigative Medicine, Instituto Gonçalo Moniz/FIOCRUZ, Salvador, Brazil.

Funding

International Exchange Program for Minority StudentsT37MD001452 · NIMHD · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI CLAUDIO, LUZ · 2005 to 2023
$4.9M
NIMHD NIH HHS T37 MD001452
6 · The paper itself

Abstract

Objectives: This study aimed to estimate the disease burden of BSIs caused by gram-negative bacteria (GNB-BSIs) in a Brazilian hospital from 2015 to 2019, measured in disability-adjusted life-years (DALYs). Methods: A retrospective cohort study of adult patients with GNB-BSI was conducted from April 01, 2015 to March 31, 2019. This study was carried out in a 356-bed private hospital with a 68-bed medical intensive care unit located in Salvador, Brazil. Demographic and clinical data were collected through a review of medical records. DALYs were estimated using Monte Carlo Simulations, using life tables for Brazilians estimated for 2020 and the Global Burden of Diseases 2010 (GBD 2010). Results: A total of 519 GNB-BSI episodes in 498 individuals were identified. The mean age was 59.92 ± 17.97 years, with 61.1% being male. The most common bacterial infections were Conclusions: The persistently high DALYs associated with CR-GNB raise alarming concerns, potentially leading to over 300 deaths per 1000 patient days in the coming years. These findings underscore the urgency of addressing GNB-BSI as a significant public health issue in Brazil. These results are expected to provide helpful information for public health policymakers to prioritize interventions for infections due to antibiotic-resistant bacteria.

Indexed as

Bloodstream infectionsBrazilian Public HealthCarbapenem-resistant gram-negative bacteriaDisability-adjusted life-yearsGram-negative bacteria

Identifiers

PMID39188887
PMCPMC11345680

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.