Evidence map›Paper›PMID 39188835›Full record

ArticleMaedica2024

Evaluation of the Association between Insulin Resistance and Subclinical Hypothyroidism Using Triglyceride-Glucose Index: a Cross-Sectional Study.

Rinky Thakur, Samir Kumar, Rajeev Kumar Neeraj, Mohd Saleem, Chakrapani Kumar, Lalit Mohan

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Maedica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07126353 (Metabolic Risk Assessment in Prepubertal Children With Congenital Hypothyroidism), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07126353 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Metabolic Risk Assessment in Prepubertal Children With Congenital Hypothyroidism (IpoMet)

Typeobservational_patient_registrySponsorBuzzi Children's HospitalRan2025 to 2026Enrolled170ConditionsCongenital Hypothyroidism, Metabolic SyndromeArmsprospective observational study (clinical, hormonal and auxological data)
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Integrating Fetuin-A and Lipid-Based Phenotyping as Markers of Cardiometabolic Risk in Subclinical Hypothyroidism.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rinky ThakurSenior Resident, Department of Pharmacology, IGIMS, Patna, India.
Samir KumarAssistant Professor, Department of General Medicine, IGIMS, Patna, India.
Rajeev Kumar NeerajJunior Resident, Department of Pharmacology, IGIMS, Patna, India.
Mohd SaleemJunior Resident, Department of General Medicine, IGIMS, Patna, India.
Chakrapani KumarSenior Resident, Department of Pharmacology, IGIMS, Patna, India.
Lalit MohanProfessor and HOD, Department of Pharmacology, IGIMS, Patna, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThyroid disorders and diabetes mellitus are often known to co-exist, implying an interrelationship between thyroid dysfunction and insulin resistance. Triglyceride-glucose (TyG) index is a relatively new surrogate marker of insulin resistance, which is cost-effective and easily calculated with routine lab tests. Data about association of subclinical hypothyroidism (SCH) and insulin resistance, especially with reference to TyG index, is lacking.

objectivesTo evaluate the association of SCH and insulin resistance using the TyG index by comparing its value in patients with SCH and age- and gender-matched euthyroid controls. Also, to determine if there is a correlation between TyG index values and thyroid profile parameters (TSH, FT3 and FT4) in both study groups. MATERIALS AND

methodsThirty-five patients with SCH and an equal number of age- and gender-matched euthyroid controls were included in the present study. The TyG index was calculated for each group and compared. The correlation between TyG index and thyroid profile parameters (TSH, FT3 and FT4) was also assessed.

resultsThe TSH values were significantly higher in the SCH group (6.6±1.7 µIU/mL) than the control one (2.5±1.2 µIU/mL; p<0.0001). There was no significant difference in FT3 in the SCH group (2.93±0.49 pg/ mL) and the control one (3.05±0.64 pg/mL; p=0.310). The level of FT4 was also not found to be significantly different in SCH subjects (1.23±0.44 ng/dL) and controls (1.4±0.42 ng/dL; p=0.077). The TyG index values were significantly higher in the SCH group (4.8±0.2) as compared to the control one (4.7±0.2; p = 0.015). The TyG index did not show any significant correlation with the thyroid parameters in any of the two groups.

conclusionThere is a positive association between SCH and insulin resistance in terms of TyG index. This index may thus be helpful in early screening and management of such patients for insulin resistance related conditions like diabetes mellitus, metabolic syndrome and cardiovascular disorders.

Identifiers

PMID39188835
PMCPMC11345053

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