Evidence map›Paper›PMID 39188695›Full record

ArticleLeukemia research reports2024

Very late relapse of Burkitt's lymphoma in an EBV-negative patient after 20 years of complete remission.

Kmar Mrad, Nader Slama, Nouha Ben Abdeljalil, Zaineb Mlayah, Wiem Boufrikha, Abdelfattah Zakhama, Sarra Boukhris, Mohamed Adnene Laatiri

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Leukemia research reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kmar MradHematology Department, Fattouma Bourguiba University Hospital of Monastir, Avenue Farhat Hached, Monastir, 5000, Tunisia.
Nader SlamaHematology Department, Fattouma Bourguiba University Hospital of Monastir, Avenue Farhat Hached, Monastir, 5000, Tunisia.
Nouha Ben AbdeljalilPathology Department, Fattouma Bourguiba University Hospital of Monastir, Avenue Farhat Hached, Monastir, 5000, Tunisia.
Zaineb MlayahHematology Department, Fattouma Bourguiba University Hospital of Monastir, Avenue Farhat Hached, Monastir, 5000, Tunisia.
Wiem BoufrikhaHematology Department, Fattouma Bourguiba University Hospital of Monastir, Avenue Farhat Hached, Monastir, 5000, Tunisia.
Abdelfattah ZakhamaPathology Department, Fattouma Bourguiba University Hospital of Monastir, Avenue Farhat Hached, Monastir, 5000, Tunisia.
Sarra BoukhrisHematology Department, Fattouma Bourguiba University Hospital of Monastir, Avenue Farhat Hached, Monastir, 5000, Tunisia.
Mohamed Adnene LaatiriHematology Department, Fattouma Bourguiba University Hospital of Monastir, Avenue Farhat Hached, Monastir, 5000, Tunisia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Burkitt's lymphoma (BL) is an aggressive B-cell lymphoma that occurs in children and adults. It is a chemosensitive lymphoma with very exceptional cases of late relapse. We report the case of a 32-year-old male, originally from a nonendemic area for BL, who was successfully treated for abdominal BL 20 years ago. He described a two-month history of cervical swelling and a one-week history of dyspnea. Physical examination was unremarkable except for a left submandibular mass that extended to the collarbone. An ultrasound of the neck revealed cervical lymphadenopathy. The patient was submitted to a lymph node biopsy with an immunohistochemical analysis, which concluded to the diagnosis of BL. Screening for recent Epstein-Barr-Virus (EBV) infection was negative. We considered this a very late relapse (VLR) of the original disease, and the patient was treated according to the same initial protocol. Unfortunately, he suffered a second relapse and died. We report an unusual case of a VLR of nonendemic BL in an EBV-negative patient, occurring 20 years after achieving complete remission following the initial chemotherapy.

Indexed as

B-cell lymphomaBurkitt lymphomaChemotherapyRecurrence

Identifiers

PMID39188695
PMCPMC11345915

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.